about
Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21)Increased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinHypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient miceMice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normallyThe Fanconi anemia core complex is dispensable during somatic hypermutation and class switch recombination.DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseGenome-wide somatic hypermutation.Linking class-switch recombination with somatic hypermutation.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Emerging links between hypermutation of antibody genes and DNA polymerases.Splitting the difference: the germline-somatic mutation debate on generating antibody diversity.c-myc hypermutation in Burkitt's lymphoma.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.Both DNA strands of antibody genes are hypermutation targets.How the interval between prime and boost injection affects the immune response in a computational model of the immune system.Error-prone candidates vie for somatic mutationThe function of AID in somatic mutation and class switch recombination: upstream or downstream of DNA breaks.DNA-dependent protein kinase activity is not required for immunoglobulin class switching.Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.AID: a riddle wrapped in a mystery inside an enigma.Affinity-based selection and the germinal center response.V genes usage by autoantibodies and their polymorphism in autoimmune mice.Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process.DNA double-strand breaks: prior to but not sufficient in targeting hypermutation.Somatic hypermutation at A.T pairs: polymerase error versus dUTP incorporation.Remembering Michael S Neuberger (1953–2013).Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory.Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase.Somatic hypermutation of antibody genes: a hot spot warms up.Immunology (1955-1975): the natural selection theory, the two signal hypothesis and positive repertoire selection.The take-home lesson--1971.
P2860
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P2860
description
article publié dans la revue scientifique Nature
@fr
scientific article published in Nature
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в Nature в липні 1966
@uk
name
Origin of Antibody Variation
@en
Origin of Antibody Variation
@nl
type
label
Origin of Antibody Variation
@en
Origin of Antibody Variation
@nl
prefLabel
Origin of Antibody Variation
@en
Origin of Antibody Variation
@nl
P356
P1433
P1476
Origin of antibody variation
@en
P2093
P2888
P304
P356
10.1038/211242A0
P407
P577
1966-07-01T00:00:00Z
P6179
1012652303