Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.
about
Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppressionAltered nucleotide misinsertion fidelity associated with poliota-dependent replication at the end of a DNA template.The origin of a developmentally regulated Igh replicon is located near the border of regulatory domains for Igh replication and expressionAssociation of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair.Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regionsEndonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsActivation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNaseHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Chromosome translocations in multiple myelomaHypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomasAID is required to initiate Nbs1/gamma-H2AX focus formation and mutations at sites of class switchingRole for mismatch repair proteins Msh2, Mlh1, and Pms2 in immunoglobulin class switching shown by sequence analysis of recombination junctionsRole of ancillary techniques in diagnosing and subclassifying non-Hodgkin's lymphomas on fine needle aspiration cytology.DNA-dependent protein kinase inhibits AID-induced antibody gene conversion.Lineage specificity of gene expression patterns.Somatic hypermutation of immunoglobulin and non-immunoglobulin genes.DNA cleavage in immunoglobulin somatic hypermutation depends on de novo protein synthesis but not on uracil DNA glycosylaseVariable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombinationSomatic immunoglobulin hypermutation.Activation-induced cytidine deaminase accelerates clonal evolution in BCR-ABL1-driven B-cell lineage acute lymphoblastic leukemia.The RAG proteins in V(D)J recombination: more than just a nuclease.Linking class-switch recombination with somatic hypermutation.AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Mechanisms of chromosomal translocations in B cell lymphomas.Mutagenesis dependent upon the combination of activation-induced deaminase expression and a double-strand breakThe connection between transcription and genomic instability.Targeting of somatic hypermutation.Involvement of Rad18 in somatic hypermutationEmerging links between hypermutation of antibody genes and DNA polymerases.DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutationThe roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae.AID and mismatch repair in antibody diversification.BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Hyper-IgM syndrome type 4 with a B lymphocyte-intrinsic selective deficiency in Ig class-switch recombination.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasRisk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes
P2860
Q24303987-90D2C30C-92E9-4859-A7A1-C80C6122CB25Q24535441-92AEFE77-9AF4-4BCA-AE2F-4F8276019CC6Q24536200-BAB0AC4A-796B-486D-884E-8BD363B38D30Q24540101-B265757F-21CE-4188-B00E-6BE022014725Q24555214-F3A31E4F-9FAA-407E-B0BD-2A5FB31D31F0Q24623341-A3CD282D-3E46-4EB9-A102-CD65D0B0EF63Q24683335-5B18673B-B7CD-4289-AEFD-740EF924617CQ27469843-225C8A2B-372C-44D1-AA5F-E0DD8CBFD4A1Q28199347-95BB72FB-25C7-4CF4-96D5-0070AA879DD7Q28207345-8D21EA95-5682-423C-8715-F7A814AC65EAQ28366125-2726954C-E3FE-4284-B117-FB9119F61BC6Q28513507-2E929498-35D0-4130-AF50-4EAC7C373245Q33256872-C5A3DE56-B494-48DF-8317-891CDB7B9BF3Q33278104-F60CC5DA-2B40-4250-A6A8-CBD625A28DB5Q33695334-1B3CB9E9-FE85-473F-B00B-4029B470F4B6Q33770250-89AF79A0-F6AE-4F6A-8AF1-91A48CAA8184Q33837311-7AC5FB79-AB4A-40EA-BC4B-068CD7B08E12Q33950143-1F40A9B0-BDA9-4A91-9529-617B72939B88Q34116350-B57A7C3E-AA02-49FB-A0E2-C298661D9AD4Q34168766-69B65367-2B77-47FB-933A-3A425A881AF5Q34194287-A902C39B-5FB9-4B06-95DF-6890ED43D583Q34297090-8A92A46B-B2E7-4759-9FD2-05B1E7E382F9Q34328206-DF42B978-5358-4CD3-9378-D77377CF3528Q34405423-226782F2-25A3-46E4-A2CB-364BC780970CQ34504886-6845F681-CC6E-4AED-9EF6-A96A0EECD337Q34514282-4CFD25A8-9B73-4830-8A4D-44EC51677761Q34551108-A8F2FAA5-4746-4B31-BF63-6C789F10D344Q34551859-F4CE8ACA-E67A-40B9-9D19-108D235D7132Q34572184-0D93AA2A-E470-41CE-895A-A5F6A0F624C6Q34612364-4BA3CEB2-1A4E-45B6-8E18-3DEB54EEB328Q34616322-0D478884-3EC8-4799-AA86-030CF10CCA80Q34770418-F805C06E-CD80-4CA4-9D9A-CCBBC00D4B11Q35022527-0272DB37-CDF2-464B-8E8A-5D11311FAF15Q35068183-A6060E62-E503-4CD2-80AD-FBDFF260C325Q35108519-B55289F1-E4BB-4E79-82AE-BB51929101ABQ35119826-76DD8F29-D5FB-48C3-BBF1-BA4DB2CD89D1Q35164207-2E2FF613-678B-43F0-B9F6-F2B94F1C96E9Q35213276-A50CC8AA-3139-4DC2-B846-CB76231EB1D5Q35792957-E3999CAC-405E-4DF3-A564-D3B3B9095497Q35849056-6164CFF7-4312-4378-A9DD-E3B1A26B87BE
P2860
Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Cell-cycle-regulated DNA doubl ...... ation of immunoglobulin genes.
@en
type
label
Cell-cycle-regulated DNA doubl ...... ation of immunoglobulin genes.
@en
prefLabel
Cell-cycle-regulated DNA doubl ...... ation of immunoglobulin genes.
@en
P2860
P356
P1433
P1476
Cell-cycle-regulated DNA doubl ...... ation of immunoglobulin genes.
@en
P2093
Papavasiliou FN
P2860
P2888
P304
P356
10.1038/35041599
P407
P577
2000-11-01T00:00:00Z
P6179
1017441998