about
The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instabilityTransactivation specificity is conserved among p53 family proteins and depends on a response element sequence codeEffect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast.Functional analysis of human FEN1 in Saccharomyces cerevisiae and its role in genome stabilityOkazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nickCohesin Is limiting for the suppression of DNA damage-induced recombination between homologous chromosomesp53 transactivation and the impact of mutations, cofactors and small molecules using a simplified yeast-based screening systemBase damage within single-strand DNA underlies in vivo hypermutability induced by a ubiquitous environmental agentQuantitative Analysis of NF-κB Transactivation Specificity Using a Yeast-Based Functional AssayDivergent evolution of human p53 binding sites: cell cycle versus apoptosisTransformation-associated recombination (TAR) cloning of tumor-inducing Xmrk2 gene from Xiphophorus maculatus.Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae.RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break endsSpecific cloning of human DNA as yeast artificial chromosomes by transformation-associated recombinationGenome-wide model for the normal eukaryotic DNA replication fork.Functionally distinct polymorphic sequences in the human genome that are targets for p53 transactivation.Mutant TP53 posttranslational modifications: challenges and opportunities.The Toll-like receptor gene family is integrated into human DNA damage and p53 networks.Alkylation base damage is converted into repairable double-strand breaks and complex intermediates in G2 cells lacking AP endonuclease.Blunt-ended DNA double-strand breaks induced by endonucleases PvuII and EcoRV are poor substrates for repair in Saccharomyces cerevisiae.A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.Requirement for end-joining and checkpoint functions, but not RAD52-mediated recombination, after EcoRI endonuclease cleavage of Saccharomyces cerevisiae DNA.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional networkDifferential transactivation by the p53 transcription factor is highly dependent on p53 level and promoter target sequence.Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells.Comparative evaluation of genetic toxicity patterns of carcinogens and noncarcinogens: strategies for predictive use of short-term assays.A multistep genomic screen identifies new genes required for repair of DNA double-strand breaks in Saccharomyces cerevisiae.Break-induced replication is a source of mutation clusters underlying kataegisSuppression of allelic recombination and aneuploidy by cohesin is independent of Chk1 in Saccharomyces cerevisiae.Damage-induced localized hypermutability.Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.The role of recombination and RAD52 in mutation of chromosomal DNA transformed into yeastDifferential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virusImpact of mitochondria on nuclear genome stability.Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.Reduced replication: a call to ARMS.Functional diversity in the gene network controlled by the master regulator p53 in humans.Low-level p53 expression changes transactivation rules and reveals superactivating sequences.
P50
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P50
description
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Michael A Resnick
@ast
Michael A Resnick
@en
Michael A Resnick
@es
Michael A Resnick
@nl
type
label
Michael A Resnick
@ast
Michael A Resnick
@en
Michael A Resnick
@es
Michael A Resnick
@nl
prefLabel
Michael A Resnick
@ast
Michael A Resnick
@en
Michael A Resnick
@es
Michael A Resnick
@nl
P106
P31
P496
0000-0002-8473-7506