A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk. - Wikidata - wikimedia - TriplyDB

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

http://www.wikidata.org/entity/Q33958881

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Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity The 3'-->5' exonuclease of DNA polymerase delta can substitute for the 5' flap endonuclease Rad27/Fen1 in processing Okazaki fragments and preventing genome instability Advances in mechanisms of genetic instability related to hereditary neurological diseases.The multiple biological roles of the 3'-->5' exonuclease of Saccharomyces cerevisiae DNA polymerase delta require switching between the polymerase and exonuclease domains Genetic dissection of parallel sister-chromatid cohesion pathways.Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion Reconstituted Okazaki fragment processing indicates two pathways of primer removal.Interactions among DNA ligase I, the flap endonuclease and proliferating cell nuclear antigen in the expansion and contraction of CAG repeat tracts in yeast Okazaki fragment maturation in yeast. II. Cooperation between the polymerase and 3'-5'-exonuclease activities of Pol delta in the creation of a ligatable nick Mechanism whereby proliferating cell nuclear antigen stimulates flap endonuclease 1 RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair.RAD50 is required for efficient initiation of resection and recombinational repair at random, gamma-induced double-strand break ends Rad52/Rad59-dependent recombination as a means to rectify faulty Okazaki fragment processing.Adeno-associated virus (AAV) site-specific recombination does not require a Rep-dependent origin of replication within the AAV terminal repeat.Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 AND DNA2.The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.Functional regulation of FEN1 nuclease and its link to cancer EXO1 and MSH6 are high-copy suppressors of conditional mutations in the MSH2 mismatch repair gene of Saccharomyces cerevisiae.A DNA polymerase epsilon mutant that specifically causes +1 frameshift mutations within homonucleotide runs in yeast.Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase).The Rad27 (Fen-1) nuclease inhibits Ty1 mobility in Saccharomyces cerevisiae.Characterization of the hyperrecombination phenotype of the pol3-t mutation of Saccharomyces cerevisiae Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection.Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer Two modes of FEN1 binding to PCNA regulated by DNA.A fluorescent bimolecular complementation screen reveals MAF1, RNF7 and SETD3 as PCNA-associated proteins in human cells Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.The trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Base excision repair: contribution to tumorigenesis and target in anticancer treatment paradigms Sister chromatid cohesion establishment occurs in concert with lagging strand synthesis.Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.Multiplexed and microparticle-based analyses: quantitative tools for the large-scale analysis of biological systems.Resolving individual steps of Okazaki-fragment maturation at a millisecond timescale.Chromosome Duplication in Saccharomyces cerevisiae.

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A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

http://www.wikidata.org/entity/Q33958881

description

1999 nî lūn-bûn

@nan

1999 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի օգոստոսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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name

A novel role in DNA metabolism ...... implications for genetic risk.

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A novel role in DNA metabolism ...... implications for genetic risk.

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type

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A novel role in DNA metabolism ...... implications for genetic risk.

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A novel role in DNA metabolism ...... implications for genetic risk.

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A novel role in DNA metabolism ...... implications for genetic risk.

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A novel role in DNA metabolism ...... implications for genetic risk.

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Molecular and Cellular Biology

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A novel role in DNA metabolism ...... implications for genetic risk

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H L Cornelius

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H T Tran

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J P Nolan

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K S Lobachev

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M S Park

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O G Kozyreva

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R Gary

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P2860

Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity

Human DNA-(Cytosine-5) Methyltransferase-PCNA Complex as a Target for p21WAF1

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2

Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair.

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5373-5382

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scholarly article

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10.1128/MCB.19.8.5373

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8

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19

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Dmitry A. Gordenin

Michael A Resnick

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1999-08-01T00:00:00Z

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10409728

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84380

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