Signal transduction by the platelet-derived growth factor receptor
about
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunitTyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transductionFunctions of the major tyrosine phosphorylation site of the PDGF receptor beta subunitIndependent expression of human alpha or beta platelet-derived growth factor receptor cDNAs in a naive hematopoietic cell leads to functional coupling with mitogenic and chemotactic signaling pathwaysPhosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivoHuman platelet-derived growth factor A chain is transcriptionally repressed by the Wilms tumor suppressor WT1Mechanism of kinase activation in the receptor for colony-stimulating factor 1Molecular cloning of HEK, the gene encoding a receptor tyrosine kinase expressed by human lymphoid tumor cell linesGenetic characteristics and research progress of targeted therapy in squamous cell carcinomaReceptor tyrosine kinase signaling: regulating neural crest development one phosphate at a timeThe conserved box 1 motif of cytokine receptors is required for association with JAK kinasesActivation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cellsIsolation and characterization of the alpha platelet-derived growth factor receptor from rat olfactory epitheliumK-sam, an amplified gene in stomach cancer, is a member of the heparin-binding growth factor receptor genesPlatelet-derived growth factor receptor mediates activation of ras through different signaling pathways in different cell typesStructural design and molecular evolution of a cytokine receptor superfamilyp85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.SH3--an abundant protein domain in search of a function.SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma.Thrombin-induced mitogenesis of vascular SMC is partially mediated by autocrine production of PDGF-AA.Molecular genetics of neurological tumoursThree dimensional structure of the transmembrane region of the proto-oncogenic and oncogenic forms of the neu protein.Image correlation spectroscopy. II. Optimization for ultrasensitive detection of preexisting platelet-derived growth factor-beta receptor oligomers on intact cellsEvaluation of everolimus in renal cell cancer.Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activityDevelopment and postnatal regulation of adult myoblasts.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.Coexpression of phosphotyrosine-containing proteins, platelet-derived growth factor-B, and fibroblast growth factor-1 in situ in synovial tissues of patients with rheumatoid arthritis and Lewis rats with adjuvant or streptococcal cell wall arthritisFluid shear stress differentially modulates expression of genes encoding basic fibroblast growth factor and platelet-derived growth factor B chain in vascular endotheliumThrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets.Cell-specific cyclic AMP-mediated induction of the PDGF receptorPhosphorylation of the PDGF receptor beta subunit creates a tight binding site for phosphatidylinositol 3 kinaseInterrupting autocrine ligand-receptor binding: comparison between receptor blockers and ligand decoys.Angiotensin II induces delayed mitogenesis and cellular proliferation in rat aortic smooth muscle cells. Correlation with the expression of specific endogenous growth factors and reversal by suramin.PDGF upregulates Mcl-1 through activation of β-catenin and HIF-1α-dependent signaling in human prostate cancer cells.Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor.High-order fluorescence fluctuation analysis of model protein clusters.Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C
P2860
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P2860
Signal transduction by the platelet-derived growth factor receptor
description
1989 nî lūn-bûn
@nan
1989 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1989 թվականի մարտին հրատարակված գիտական հոդված
@hy
1989年の論文
@ja
1989年論文
@yue
1989年論文
@zh-hant
1989年論文
@zh-hk
1989年論文
@zh-mo
1989年論文
@zh-tw
1989年论文
@wuu
name
Signal transduction by the platelet-derived growth factor receptor
@ast
Signal transduction by the platelet-derived growth factor receptor
@en
Signal transduction by the platelet-derived growth factor receptor
@nl
type
label
Signal transduction by the platelet-derived growth factor receptor
@ast
Signal transduction by the platelet-derived growth factor receptor
@en
Signal transduction by the platelet-derived growth factor receptor
@nl
prefLabel
Signal transduction by the platelet-derived growth factor receptor
@ast
Signal transduction by the platelet-derived growth factor receptor
@en
Signal transduction by the platelet-derived growth factor receptor
@nl
P3181
P356
P1433
P1476
Signal transduction by the platelet-derived growth factor receptor
@en
P2093
L T Williams
P304
P3181
P356
10.1126/SCIENCE.2538922
P407
P577
1989-03-24T00:00:00Z