Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes
about
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activationFunctional association between SLAP-130 and SLP-76 in Jurkat T cellsPhosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activationSKAP55 coupled with CD45 positively regulates T-cell receptor-mediated gene transcriptionRegulation of FynT function by dual domain docking on PAG/CbpRegulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor proteinSubstrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrateMolecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sitesFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsT cell receptor (TCR) interacting molecule (TRIM), a novel disulfide-linked dimer associated with the TCR-CD3-zeta complex, recruits intracellular signaling proteins to the plasma membraneAn essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55RThe ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activationSH3 domain recognition of a proline-independent tyrosine-based RKxxYxxY motif in immune cell adaptor SKAP55The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular SwitchSKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activationDeficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cellsMolecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130SKAP-HOM, a novel adaptor protein homologous to the FYN-associated protein SKAP55Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cellsHematopoietic adaptors in T-cell signaling: potential applications to transplantationRegulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motilityADAP is required for normal alphaIIbbeta3 activation by VWF/GP Ib-IX-V and other agonists.The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domainAdaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells.The role of the adapter molecule SLP-76 in platelet function.Adapters in the organization of mast cell signaling.Adapters in lymphocyte signalingSignalling scaffolds and adaptors in T-cell immunity.T-cell receptor signaling to integrins.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Positive and negative adaptors in T-cell signalling.Regulation of T-cell receptor signalling by membrane microdomains.Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes.Compartmentalization of ITAM and integrin signaling by adapter molecules.Regulation of T-cell antigen receptor-mediated inside-out signaling by cytosolic adapter proteins and Rap1 effector molecules.Distinct regulation of integrin-dependent T cell conjugate formation and NF-kappa B activation by the adapter protein ADAP.Role of NF-kappa B in cell survival and transcription of latent membrane protein 1-expressing or Epstein-Barr virus latency III-infected cells.SKAP-55, SKAP-55-related and ADAP adaptors modulate integrin-mediated immune-cell adhesion.
P2860
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P2860
Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@ast
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en-gb
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@nl
type
label
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@ast
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en-gb
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@nl
prefLabel
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@ast
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en-gb
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@nl
P2093
P2860
P3181
P356
P1476
Molecular cloning of SKAP55, a ...... p59fyn in human T-lymphocytes
@en
P2093
A Marie-Cardine
B Schraven
C Eckerskorn
H Kirchgessner
P2860
P304
P3181
P356
10.1074/JBC.272.26.16077
P407
P577
1997-06-27T00:00:00Z