ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation
about
Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cellsCoordination of DNA damage responses via the Smc5/Smc6 complexSumoylation of the novel protein hRIP{beta} is involved in replication protein A deposition in PML nuclear bodiesATRIP binding to replication protein A-single-stranded DNA promotes ATR-ATRIP localization but is dispensable for Chk1 phosphorylationMammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factorsQuaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activitiesATR checkpoint kinase and CRL1βTRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks.ND10 components relocate to sites associated with herpes simplex virus type 1 nucleoprotein complexes during virus infection.DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.A novel protein activity mediates DNA binding of an ATR-ATRIP complex.Phosphatidyl inositol 3-kinase-like serine/threonine protein kinases (PIKKs) are required for DNA damage-induced phosphorylation of the 32 kDa subunit of replication protein A at threonine 21.DNA stimulates Mec1-mediated phosphorylation of replication protein A.Recruitment of cellular recombination and repair proteins to sites of herpes simplex virus type 1 DNA replication is dependent on the composition of viral proteins within prereplicative sites and correlates with the induction of the DNA damage respoCoordinated regulation of replication protein A activities by its subunits p14 and p32.Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage.DNA damage induced hyperphosphorylation of replication protein A. 1. Identification of novel sites of phosphorylation in response to DNA damage.Modulation of replication protein A function by its hyperphosphorylation-induced conformational change involving DNA binding domain B.Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks.Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection.ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiationRPA2 is a direct downstream target for ATR to regulate the S-phase checkpoint.NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.Replication protein A: directing traffic at the intersection of replication and repair.ATR and ATRIP are recruited to herpes simplex virus type 1 replication compartments even though ATR signaling is disabled.RING finger and WD repeat domain 3 (RFWD3) associates with replication protein A (RPA) and facilitates RPA-mediated DNA damage response.Dimerization of the ATRIP protein through the coiled-coil motif and its implication to the maintenance of stalled replication forksPML-mediated signaling and its role in cancer stem cells.In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signalingATR kinase activation in G1 phase facilitates the repair of ionizing radiation-induced DNA damage.The tumor suppressor PML specifically accumulates at RPA/Rad51-containing DNA damage repair foci but is nonessential for DNA damage-induced fibroblast senescence.Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.Nesprin-2-dependent ERK1/2 compartmentalisation regulates the DNA damage response in vascular smooth muscle cell ageingDynamic targeting of the replication machinery to sites of DNA damage.Interactions between DNA viruses, ND10 and the DNA damage response.HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanismTargeting promyelocytic leukemia protein: a means to regulating PML nuclear bodiesPolymerase η suppresses telomere defects induced by DNA damaging agentsHost cell restriction factors that limit transcription and replication of human papillomavirus.Protein phosphatase 5 is required for ATR-mediated checkpoint activation.
P2860
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P2860
ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation
description
2003 nî lūn-bûn
@nan
2003 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
ATR kinase activity regulates ...... A following ionizing radiation
@ast
ATR kinase activity regulates ...... A following ionizing radiation
@en
ATR kinase activity regulates ...... A following ionizing radiation
@en-gb
ATR kinase activity regulates ...... A following ionizing radiation
@nl
type
label
ATR kinase activity regulates ...... A following ionizing radiation
@ast
ATR kinase activity regulates ...... A following ionizing radiation
@en
ATR kinase activity regulates ...... A following ionizing radiation
@en-gb
ATR kinase activity regulates ...... A following ionizing radiation
@nl
prefLabel
ATR kinase activity regulates ...... A following ionizing radiation
@ast
ATR kinase activity regulates ...... A following ionizing radiation
@en
ATR kinase activity regulates ...... A following ionizing radiation
@en-gb
ATR kinase activity regulates ...... A following ionizing radiation
@nl
P2093
P1433
P1476
ATR kinase activity regulates ...... A following ionizing radiation
@en
P2093
Cindy G Leung
Elbert E Chang
Karlene A Cimprich
Sharon M Barr
P304
P356
10.1016/S0960-9822(03)00376-2
P407
P577
2003-06-17T00:00:00Z