Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityHuman Naa50p (Nat5/San) displays both protein N alpha- and N epsilon-acetyltransferase activityCharacterization of functional domains in human ClaspinThe human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementTimeless links replication termination to mitotic kinase activationEstablishment of cohesion at the pericentromere by the Ctf19 kinetochore subcomplex and the replication fork-associated factor, Csm3Tim/Timeless, a member of the replication fork protection complex, operates with the Warsaw breakage syndrome DNA helicase DDX11 in the same fork recovery pathwayHuman Timeless and Tipin stabilize replication forks and facilitate sister-chromatid cohesionEmerging models for the molecular basis of mammalian circadian timingModulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searchesTimeless preserves telomere length by promoting efficient DNA replication through human telomeresIndividual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.An unexpected role for the clock protein timeless in developmental apoptosisPotential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analysesMeiosis genes in Daphnia pulex and the role of parthenogenesis in genome evolution.Network architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control.Light entrained rhythmic gene expression in the sea anemone Nematostella vectensis: the evolution of the animal circadian clock.Checkpoint-dependent and -independent roles of Swi3 in replication fork recovery and sister chromatid cohesion in fission yeast.Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.Coordinated degradation of replisome components ensures genome stability upon replication stress in the absence of the replication fork protection complexMCM10 mediates RECQ4 association with MCM2-7 helicase complex during DNA replicationCircadian clock, cancer, and chemotherapy.2mit, an intronic gene of Drosophila melanogaster timeless2, is involved in behavioral plasticity.Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblastsArchitecture and ssDNA interaction of the Timeless-Tipin-RPA complex.The Analysis of Pendolino (peo) Mutants Reveals Differences in the Fusigenic Potential among Drosophila Telomeres.TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival.DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase.Tipin is required for stalled replication forks to resume DNA replication after removal of aphidicolin in Xenopus egg extracts.And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stressEffect of circadian clock mutations on DNA damage response in mammalian cellsChk1 and Claspin potentiate PCNA ubiquitination.Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblastsThe human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.Integrating S-phase checkpoint signaling with trans-lesion synthesis of bulky DNA adducts.
P2860
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P2860
Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors
description
2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2007
@ast
im Februar 2007 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2007/02/09)
@sk
vědecký článek publikovaný v roce 2007
@cs
wetenschappelijk artikel (gepubliceerd op 2007/02/09)
@nl
наукова стаття, опублікована в лютому 2007
@uk
مقالة علمية (نشرت في 9-2-2007)
@ar
name
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@ast
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@en
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@nl
type
label
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@ast
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@en
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@nl
prefLabel
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@ast
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@en
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@nl
P2093
P2860
P921
P3181
P1476
Mammalian TIMELESS and Tipin a ...... cation fork-associated factors
@en
P2093
Anthony L. Gotter
Beverly S. Emanuel
Christine Suppa
P2860
P3181
P356
10.1016/J.JMB.2006.10.097
P407
P577
2007-02-09T00:00:00Z