Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26 - sprookjes - yvandenbroek - TriplyDB

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

http://www.wikidata.org/entity/Q24653892

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Regulation of nucleolar signalling to p53 through NEDDylation of L11 Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability The nucleolus under stress Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1 Guarding the 'translation apparatus': defective ribosome biogenesis and the p53 signaling pathway Diverse diseases from a ubiquitous process: the ribosomopathy paradox Systematic approaches to identify E3 ligase substrates Regulatory Roles of Rpl22 in Hematopoiesis: An Old Dog with New Tricks Dysregulation of ubiquitin ligases in cancer Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA ShRNA-targeted centromere protein A inhibits hepatocellular carcinoma growth An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction Comparative transcriptome analyses of seven anurans reveal functions and adaptations of amphibian skin Mdm2 links genotoxic stress and metabolism to p53.Ribosomopathies: human disorders of ribosome dysfunction.Deregulation of oncogene-induced senescence and p53 translational control in X-linked dyskeratosis congenita.Multiple distinct molecular mechanisms influence sensitivity and resistance to MDM2 inhibitors in adult acute myelogenous leukemia.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.Perturbation of 60 S ribosomal biogenesis results in ribosomal protein L5- and L11-dependent p53 activation MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24 Modeling the basal dynamics of p53 system.Ribosome defects in disorders of erythropoiesis.5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage.Post-transcriptional RNA regulons affecting cell cycle and proliferation.Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis Negative regulation of HDM2 to attenuate p53 degradation by ribosomal protein L26.Ubiquitin and ubiquitin-like proteins in the nucleolus: multitasking tools for a ribosome factory.The emerging importance of ribosomal dysfunction in the pathogenesis of hematologic disorders.Ribosomal proteins and human diseases: pathogenesis, molecular mechanisms, and therapeutic implications Ribosomal proteins: functions beyond the ribosome Homozygous mdm2 SNP309 cancer cells with compromised transcriptional elongation at p53 target genes are sensitive to induction of p53-independent cell death.Essential role for the interaction between hnRNP H/F and a G quadruplex in maintaining p53 pre-mRNA 3'-end processing and function during DNA damage.Miz-1 regulates translation of Trp53 via ribosomal protein L22 in cells undergoing V(D)J recombination Ribosomal protein S27-like in colorectal cancer: a candidate for predicting prognoses.Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network Screening E3 substrates using a live phage display library Interplay between ribosomal protein S27a and MDM2 protein in p53 activation in response to ribosomal stress.

P2860

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P2860

Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26

http://www.wikidata.org/entity/Q24653892

description

2008 nî lūn-bûn

@nan

2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@ast

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

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Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

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type

label

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@ast

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@en

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@nl

prefLabel

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@ast

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

@en

Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

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J.MOLCEL.2008.08.031

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Mdm2 regulates p53 mRNA transl ...... ons with ribosomal protein L26

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P2093

Kristy Boggs

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Michael B Kastan

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Moshe Oren

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Yaara Ofir-Rosenfeld

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P2860

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function

MDMX regulation of p53 response to ribosomal stress

Mdm2 promotes the rapid degradation of p53

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

The ribosomal L5 protein is associated with mdm-2 and mdm-2-p53 complexes

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10.1016/J.MOLCEL.2008.08.031

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2

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18951086

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