The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells
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Virologic Tools for HCV Drug Resistance TestingDevelopment of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralizationIntragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell deathThe Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious VirusHepatitis C virus replicons: dinosaurs still in business?Helicase inhibitors as specifically targeted antiviral therapy for hepatitis CStructural and Functional Analysis of Hepatitis C Virus Strain JFH1 PolymeraseA Comprehensive Structure-Function Comparison of Hepatitis C Virus Strain JFH1 and J6 Polymerases Reveals a Key Residue Stimulating Replication in Cell Culture across GenotypesTwo Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405RNA polymerase activity and specific RNA structure are required for efficient HCV replication in cultured cells.Development of an intergenotypic hepatitis C virus (HCV) cell culture method to assess antiviral susceptibilities and resistance development of HCV NS3 protease genes from HCV genotypes 1 to 6Inhibition of hepatitis C virus replication by single-stranded RNA structural mimics.The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase.Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.SEC14L2 enables pan-genotype HCV replication in cell culture.Production of infectious chimeric hepatitis C virus genotype 2b harboring minimal regions of JFH-1.Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Novel cell culture-adapted genotype 2a hepatitis C virus infectious cloneCombination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.Cellular and molecular biology of HCV infection and hepatitis.Hepatitis C virus: assembly and release of virus particles.Amino Acid Mutations in the NS4A Region of Hepatitis C Virus Contribute to Viral Replication and Infectious Virus ProductionHepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA.Replication and infectivity of a novel genotype 1b hepatitis C virus clone.Construction of a chimeric hepatitis C virus replicon based on a strain isolated from a chronic hepatitis C patient.Modification of hepatitis C virus 1b RNA polymerase to make a highly active JFH1-type polymerase by mutation of the thumb domain.NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA.
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P2860
The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells
description
2007 nî lūn-bûn
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2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@ast
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@en
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@nl
type
label
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@ast
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@en
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@nl
prefLabel
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@ast
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@en
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@nl
P2093
P2860
P356
P1433
P1476
The NS3 Helicase and NS5B-to-3 ...... FH-1 Replication in Huh7 Cells
@en
P2093
Asako Murayama
Daisuke Akazawa
Kenichi Morikawa
Koji Ishii
Masashi Mizokami
Michiko Miyamoto
Minako Kaga
Takanobu Kato
Tetsuro Suzuki
Tomoko Date
P2860
P304
P356
10.1128/JVI.02088-06
P577
2007-08-01T00:00:00Z