The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms - sprookjes - yvandenbroek - TriplyDB

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms

http://www.wikidata.org/entity/Q28272871

about

Molecular basis of Wnt activation via the DIX domain protein Ccd1 Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions The structural and functional determinants of the Axin and Dishevelled DIX domains Verification of predicted alternatively spliced Wnt genes reveals two new splice variants (CTNNB1 and LRP5) and altered Axin-1 expression during tumour progression.Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1.DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling.CAFET algorithm reveals Wnt/PCP signature in lung squamous cell carcinoma Ablation of MEKK4 kinase activity causes neurulation and skeletal patterning defects in the mouse embryo.An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.Intrinsic disorder in scaffold proteins: getting more from less Upregulated expression of DIXDC1 in intestinal-type gastric carcinoma: co-localization with β-catenin and correlation with poor prognosis Profibrotic role of miR-154 in pulmonary fibrosis.Role of mitogen-activated protein kinase kinase kinases in signal integration.New insights into the regulation of Axin function in canonical Wnt signaling pathway.DIXDC1 increases the invasion and migration ability of non-small-cell lung cancer cells via the PI3K-AKT/AP-1 pathway.Knockdown of DIXDC1 Inhibits the Proliferation and Migration of Human Glioma Cells.Downregulated expression of DIXDC1 in hepatocellular carcinoma and its correlation with prognosis.Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd1.The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling.

P2860

Q24321730-674265ED-7AB8-461A-9716-CB3DBAF31A91 Q24630980-08CB0200-18CF-4412-821A-68D2AC4BC79F Q28591541-743B9D60-BA2A-47E5-8C5F-D9C9AF4993E9 Q30883598-AEDDE95C-5885-4418-BEEE-DB7A4F269E89 Q33246692-E2FE4028-7BB9-448C-8E70-07D1B4FC1AC8 Q33404575-8A1A5259-5032-4ECF-83BD-8FC8A63FAEDB Q33574930-C4AAFBA8-E0C1-4788-8421-9E2B319314B1 Q34053334-1617CDBB-12DB-44F0-AA46-FF47AE4EDBC4 Q34097247-E6E008F5-AA94-455D-BEBB-4022413CDDE2 Q34117181-8573294A-53DB-4E71-8869-F4E89D79CDE0 Q34594105-C10D2B0A-37EA-41A5-9A7E-58AE951082A0 Q36383885-7D57CD49-5EF9-42A5-93EC-3C40DBE5809A Q36539603-735DB72A-E1A6-4DCB-A744-799B44363257 Q36819381-A5B09E8A-7992-4B7B-ADA6-A4ABAA961277 Q37666459-F26353D3-0FC4-480D-BED4-D4A2FE83005E Q39132714-A05404D3-348C-4145-8D30-F6AAB7E7B15A Q39211801-BDCA518B-21E4-4C03-BD28-E320AB3DB32E Q39549724-B0013262-4C1B-4E6D-8417-E9D247285836 Q42000264-D78CC712-A324-4122-BE52-ACC55ABD7FE4 Q50636049-5342E2AF-F5DA-4E68-8AFE-C052329DA741

P2860

The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms

http://www.wikidata.org/entity/Q28272871

description

2004 nî lūn-bûn

@nan

2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2004年の論文

@ja

2004年論文

@yue

2004年論文

@zh-hant

2004年論文

@zh-hk

2004年論文

@zh-mo

2004年論文

@zh-tw

2004年论文

@wuu

name

The DIX domain protein coiled- ...... ed through distinct mechanisms

@ast

The DIX domain protein coiled- ...... ed through distinct mechanisms

@en

The DIX domain protein coiled- ...... ed through distinct mechanisms

@nl

type

label

The DIX domain protein coiled- ...... ed through distinct mechanisms

@ast

The DIX domain protein coiled- ...... ed through distinct mechanisms

@en

The DIX domain protein coiled- ...... ed through distinct mechanisms

@nl

prefLabel

The DIX domain protein coiled- ...... ed through distinct mechanisms

@ast

The DIX domain protein coiled- ...... ed through distinct mechanisms

@en

The DIX domain protein coiled- ...... ed through distinct mechanisms

@nl

P1433

Q28272871-80824A64-A9D4-4AF6-851B-9A0851449304

P1476

Q28272871-ED5858C0-E61D-4F6A-A4A5-0D5F7918D407

P2093

Q28272871-58FE8A83-F73E-4EE9-8CC1-15D9DA997A95

Q28272871-6E426199-CF01-4399-BAD7-8AEE340CD1EA

Q28272871-7711529A-F4DD-410D-8B65-963A10707EAF

Q28272871-9B3750E8-15D3-44D8-8AC5-56D57591F9AE

Q28272871-DCF655E0-353E-4D4E-A4E3-617C4AEE95BE

Q28272871-FFDD8141-F9B3-4723-8E27-56CA66068C59

P2860

Q28272871-021911D0-1831-450D-B9FC-F950C081C6B2

Q28272871-0E6AC861-F32B-43F0-A8A4-BBB570AACA99

Q28272871-10A0F7C2-9288-4FF0-BF52-8FD513A86C81

Q28272871-187CC260-B029-430F-A355-559FA3E058D2

Q28272871-26060A74-A45F-4244-BD3B-C4F9088753BE

Q28272871-3E57C76B-4FCF-4372-A456-9EB9A8294C9C

Q28272871-41DBCF00-3A68-48D4-B6D5-32E06ABF73A3

Q28272871-4FE75D4D-1468-4883-8517-20D4CDC57DD4

Q28272871-5C7E2B7C-4E3E-41AF-A9B7-E061F850CC5B

Q28272871-6103E614-BE40-4023-AAC5-4F69E893207A

P304

Q28272871-F83FC38E-1D9C-4418-9464-3857E330FC1E

P31

Q28272871-FFD4DCD9-8BBB-431A-A305-843BDDFFF69C

P356

Q28272871-A56E7DFD-888B-430C-87DB-90BC920DBCBE

P407

Q28272871-9E490F56-7745-440A-8C5F-5D314431420F

P433

Q28272871-4D16BC95-1FDF-4CFE-8FD9-FBFA96C477FF

P478

Q28272871-ADA11ED7-90B4-4B3B-8287-4465CBC25BA4

P577

Q28272871-76E67001-27B9-446A-AD78-B5126B28CACA

P698

Q28272871-E3136C14-3E00-4E2C-AA81-C5FAC51F8A70

P356

P1433

Journal of Biological Chemistry

P1476

The DIX domain protein coiled- ...... ed through distinct mechanisms

@en

P2093

Chung Kai Wong

http://www.w3.org/2001/XMLSchema#string

Haiying Zou

http://www.w3.org/2001/XMLSchema#string

Sheng-Cai Lin

http://www.w3.org/2001/XMLSchema#string

Wen Luo

http://www.w3.org/2001/XMLSchema#string

Ying Deng

http://www.w3.org/2001/XMLSchema#string

Zhiyun Ye

http://www.w3.org/2001/XMLSchema#string

P2860

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin.

Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex

Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1.

Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase

Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation

P304

39366-73

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M404598200

http://www.w3.org/2001/XMLSchema#string

P407

P433

38

http://www.w3.org/2001/XMLSchema#string

P478

279

http://www.w3.org/2001/XMLSchema#string

P577

2004-09-17T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15262978

http://www.w3.org/2001/XMLSchema#string