Rapamycin extends murine lifespan but has limited effects on aging.
about
Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging MoleculesINFRAFRONTIER: a European resource for studying the functional basis of human diseaseGeroscience approaches to increase healthspan and slow agingInhibition of the Mechanistic Target of Rapamycin (mTOR)-Rapamycin and BeyondThe role of the ribosome in the regulation of longevity and lifespan extensionBiochemical Genetic Pathways that Modulate Aging in Multiple SpeciesMYC, Metabolism, and CancerIdentification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.Reduced expression of MYC increases longevity and enhances healthspan.Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairmentsPotential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disordersLongevity and skeletal muscle mass: the role of IGF signalling, the sirtuins, dietary restriction and protein intakeEssential role for autophagy in life span extensionmTOR signaling in tumorigenesisIntermittent Administration of Rapamycin Extends the Life Span of Female C57BL/6J MiceRapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restrictionLifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycinTemsirolimus Partially Rescues the Hutchinson-Gilford Progeria Cellular Phenotype17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodelingEffect of Chronic Administration of Low Dose Rapamycin on Development and Immunity in Young Rats10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin SignalingPleiotropic functions for transcription factor zscan10.High-dose maternal folic acid supplementation before conception impairs reversal learning in offspring mice.Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging.Preserving youth: does rapamycin deliver?Recent progress in metabolic signaling pathways regulating aging and life spanAltered proteome turnover and remodeling by short-term caloric restriction or rapamycin rejuvenate the aging heart.Longevity pathways and memory agingeRapa restores a normal life span in a FAP mouse model.Sirtuins: guardians of mammalian healthspan.In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry.Immune memory-boosting dose of rapamycin impairs macrophage vesicle acidification and curtails glycolysis in effector CD8 cells, impairing defense against acute infectionsBiotechnological applications derived from microorganisms of the Atacama DesertAcute mTOR inhibition induces insulin resistance and alters substrate utilization in vivoTissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice.Berberine suppresses gero-conversion from cell cycle arrest to senescence.Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver.Longevity, aging and rapamycin.Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset.
P2860
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P2860
Rapamycin extends murine lifespan but has limited effects on aging.
description
2013 nî lūn-bûn
@nan
2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Rapamycin extends murine lifespan but has limited effects on aging.
@ast
Rapamycin extends murine lifespan but has limited effects on aging.
@en
type
label
Rapamycin extends murine lifespan but has limited effects on aging.
@ast
Rapamycin extends murine lifespan but has limited effects on aging.
@en
prefLabel
Rapamycin extends murine lifespan but has limited effects on aging.
@ast
Rapamycin extends murine lifespan but has limited effects on aging.
@en
P2093
P2860
P50
P356
P1476
Rapamycin extends murine lifespan but has limited effects on aging.
@en
P2093
Andreas Zimmer
Beatrix Naton
Birgit Rathkolb
Dan Ehninger
Diana Flores-Dominguez
Dirk H Busch
Frauke Neff
Heinz Höfler
Helmut Fuchs
Ildikó Rácz
P2860
P304
P356
10.1172/JCI67674
P407
P50
P577
2013-07-25T00:00:00Z