Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex. - sprookjes - yvandenbroek - TriplyDB

Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

http://www.wikidata.org/entity/Q30987095

about

Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3 Deficiency of huntingtin has pleiotropic effects in the social amoeba Dictyostelium discoideum Using the social amoeba Dictyostelium to study the functions of proteins linked to neuronal ceroid lipofuscinosis Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana.Crystal structure of the γ-secretase component nicastrin.Structure of nicastrin unveils secrets of γ-secretase Bio-electrospraying and aerodynamically assisted bio-jetting the model eukaryotic Dictyostelium discoideum: assessing stress and developmental competency post treatment.The cryo-electron microscopy structure of γ-Secretase: towards complex assembly, substrate recognition and a catalytic mechanism.Non-Catalytic Roles of Presenilin Throughout Evolution.An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.Clues to γ-secretase, huntingtin and Hirano body normal function using the model organism Dictyostelium discoideum.The very many faces of presenilins and the γ-secretase complex.Regulated intramembrane proteolysis of the TGFβ type I receptor conveys oncogenic signals.Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease.Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum.Aberrant adhesion impacts early development in a Dictyostelium model for juvenile neuronal ceroid lipofuscinosis.Bestatin inhibits cell growth, cell division, and spore cell differentiation in Dictyostelium discoideum.Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum.Presenilins as Drug Targets for Alzheimer's Disease-Recent Insights from Cell Biology and Electrophysiology as Novel Opportunities in Drug Development.Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in

P2860

Q27321366-559A0240-78A9-41FB-9322-00570868452C Q27334931-6FD54B02-593E-4FC9-B1D6-80190078C017 Q27341119-D76CDB38-DADE-45B5-A38E-C5D287D7D743 Q28071411-898372D1-66DF-45CA-8C82-091BDE52F645 Q33809866-9F0BE409-99F5-4E33-B18D-BC43E20B3700 Q34218060-675EE798-9266-49E8-B63C-A1E3EEA3EA04 Q34384209-E8957059-87EF-4726-830A-24B97F6C45AC Q35059366-A2922EAB-E22E-4DC6-AC2B-17F008780F57 Q35743774-74071CB2-29E9-4DCE-83C7-5FDFB8DA0919 Q37053791-A9E97D86-B299-4D74-BDA7-3A8F8BFB7630 Q37674691-419920AB-E683-4F5D-8EA5-919B004CCFD7 Q38001474-EEA4C311-CBFC-4B8E-9BDB-169C2313DE2E Q38090514-EA0D6F50-FF0C-4C96-863A-7B81057E51C3 Q38193549-C78AB219-1958-4FEB-A18E-6A7BB04799C2 Q39041998-39CC9A22-620C-4B66-A51E-15F114265C2D Q39411013-03D25E64-03C8-4F6D-95C4-C2F5DCC61324 Q41510250-643E7091-193C-4EF6-93B8-005E96DAF641 Q42559117-0E3B7448-2359-4FFD-A4B1-FF6BC2C7461C Q47552746-8DA1FE6B-2C26-4FA4-97B8-1DAC25067C57 Q55690547-0788A119-9EED-473A-8911-CE0FD30277E4 Q58704340-AE9143E4-52FF-4AD0-B28A-1B5951690641

P2860

Dictyostelium possesses highly diverged presenilin/gamma-secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/gamma-secretase complex.

http://www.wikidata.org/entity/Q30987095

description

2010 nî lūn-bûn

@nan

2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի օգոստոսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@ast

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@en

type

label

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@ast

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@en

prefLabel

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@ast

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@en

P1433

Q30987095-CDEB529A-8C54-4FFA-855C-24A07B7C9649

P1476

Q30987095-89E47413-B6D9-4D5D-883C-8526A0740E9B

P2093

Q30987095-5EBC7E7E-A741-4D74-B3D8-23CE1B9E71B1

Q30987095-8165F66F-6275-46D7-9C4F-0C637B3452AD

Q30987095-DA033D8D-60BB-4903-AB80-4C851556D447

Q30987095-F404767C-1708-4BE6-8991-792534C94ABC

P2860

Q30987095-088E72E5-EF22-45F7-B693-CC85FBE7BD79

Q30987095-0DF7E628-4D46-43AA-9B49-AC4C55F3AD03

Q30987095-10850AC7-75FC-4505-A0E9-71320ECBC628

Q30987095-10C361F1-0DB6-4065-A54A-4C61378C892B

Q30987095-163462C6-40BD-45F7-9BD0-2DD5AC0CCF7A

Q30987095-222380C7-ADED-4D26-9E16-76D2144BC250

Q30987095-246F47F8-5545-4687-B598-EE8B7E33DC31

Q30987095-2A720D80-221A-4204-956E-1AABA1A92114

Q30987095-2B199E1E-594D-4030-9AE3-63777C337675

Q30987095-2B615B0B-C96A-422A-9244-263D5337F491

P304

Q30987095-44696024-8B70-4C9F-B2FE-1150C898D90F

P31

Q30987095-0C95AD93-BCEB-41EA-918C-1B14814B0322

P356

Q30987095-1B6BFEBA-85F6-4F6F-B3B8-D8478162DFB0

P433

Q30987095-5E402744-AA63-483C-807F-D103C7E7D448

P478

Q30987095-9E133C8C-A17E-489B-855C-0F9CDBF5B015

P577

Q30987095-8108C340-F3A6-4F4B-B6AD-5981D056F3B5

P698

Q30987095-26567D2C-238A-49D6-AACE-1C4500337A01

P932

Q30987095-EEDFE9F7-0AD0-4438-B60A-2B19AC3FFE1B

P356

P1433

Disease Models & Mechanisms

P1476

Dictyostelium possesses highly ...... nilin/gamma-secretase complex.

@en

P2093

Alan R Kimmel

http://www.w3.org/2001/XMLSchema#string

Lisa Kreppel

http://www.w3.org/2001/XMLSchema#string

Michael Myre

http://www.w3.org/2001/XMLSchema#string

Vanessa C McMains

http://www.w3.org/2001/XMLSchema#string

P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Immune-like phagocyte activity in the social amoeba

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

P304

581-594

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1242/DMM.004457

http://www.w3.org/2001/XMLSchema#string

P433

9-10

http://www.w3.org/2001/XMLSchema#string

P478

3

http://www.w3.org/2001/XMLSchema#string

P577

2010-08-10T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

20699477

http://www.w3.org/2001/XMLSchema#string

P932

2931536

http://www.w3.org/2001/XMLSchema#string