Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
about
Islet inflammation: a unifying target for diabetes treatment?Lipotoxicity in the pancreatic beta cell: not just survival and function, but proliferation as well?Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acidDeletion of 12/15-lipoxygenase alters macrophage and islet function in NOD-Alox15(null) mice, leading to protection against type 1 diabetes developmentPotent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapiesGene-environment interaction models to unmask susceptibility mechanisms in Parkinson's disease.Evidence of contribution of iPLA2β-mediated events during islet β-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2β in T1D development.12-lipoxygenase promotes obesity-induced oxidative stress in pancreatic islets.Minireview: 12-Lipoxygenase and Islet β-Cell Dysfunction in Diabetes.Inhibition of Ca2+-independent phospholipase A2β (iPLA2β) ameliorates islet infiltration and incidence of diabetes in NOD mice.Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.Interleukin-12 (IL-12)/STAT4 Axis Is an Important Element for β-Cell Dysfunction Induced by Inflammatory Cytokines.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.The incretin effect in critically ill patients: a case-control study.Angiotensin II stimulates superoxide production in the thick ascending limb by activating NOX4.Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: attenuation of oxidative and nitrosative stress by 2-bromopalmitate.Lipids and immunoinflammatory pathways of beta cell destruction.Impact of Long-Term Poor and Good Glycemic Control on Metabolomics Alterations in Type 1 Diabetic PeopleImpaired beta cell function is present in nondiabetic rheumatoid arthritis patients12-Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular diseasePseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenasesMicroarray analysis of rat pancreas reveals altered expression of Alox15 and regenerating islet-derived genes in response to iron deficiency and overload.Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetesCertain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.Differential contribution of lipoxygenase isozymes to nigrostriatal vulnerability.β-cell differentiation status in type 2 diabetes.Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction.NOX, NOX Who is There? The Contribution of NADPH Oxidase One to Beta Cell Dysfunction.Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetesStrict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)Inhibition of NADPH oxidase-1 preserves beta cell function.Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate.Redox-Sensitive Innate Immune Pathways During Macrophage Activation in Type 1 Diabetes.The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice.Type 1 diabetes alters lipid handling and metabolism in human fibroblasts and peripheral blood mononuclear cells.Tumour necrosis factor-alpha infusion produced insulin resistance but no change in the incretin effect in healthy volunteers.β-Cell Autophagy in Diabetes Pathogenesis.The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
P2860
Q26860847-D5D8E3D4-428E-4C79-A484-6CBD14D2EA85Q26866054-133961C7-0197-4D8C-8DFA-E3AADCD112A1Q28252674-8BCEC5D6-AC39-4D3A-9101-98D9D3A08105Q30422344-09754374-3648-454A-AA84-EA437C074518Q33662463-6D674082-D683-4349-91E1-41942BFCA2F6Q33872463-D21D47AF-CEF2-45DD-A65E-47CE5EAD5DC2Q34068396-0095E786-A48A-4644-8831-BE1554EFCF6DQ34298029-20F4C4E4-82B2-4447-B065-AB53FED93231Q34468392-B8A8A258-D4AD-4BC0-84D5-8C70ED2319D6Q35004275-3AC6A400-ABCF-49E6-AF1D-97011154BD7CQ35536316-3AFE0209-11D7-496B-B4C9-5A3C1B6B2202Q35837421-C33F343D-98C0-41EB-9C8F-A179CC8C8497Q35994344-F14E441F-716C-4E92-8F9D-1E7936267D39Q36281505-AE321CDD-E826-41B9-9625-55DE2D7F6132Q36312399-0961D2F5-230B-4873-A39D-D6AD94C76623Q36488109-8943472D-37D2-477C-BBC0-A8A71ADCE0CFQ36654911-8A97ED2C-27C1-4D53-9D53-0812F587FB34Q36716070-EF80F142-1974-4B68-A20D-B66D5ADB3179Q36903389-1916AB3E-681E-47B8-8D15-7FE7A446DCE4Q36939224-EC414928-3602-4D07-8A76-D016C9252736Q37184330-1F58A8AE-28F4-4505-8AE5-AFAA723AE1F6Q37192356-B17E5885-192F-48E0-B06A-C9EE7FA267B8Q37500045-6A801F7B-83EA-41AF-82B4-709D4BA1D288Q37664028-46536891-4880-4FB2-807A-17CA3A8F3710Q38268646-66F38522-D282-46F5-830C-5540E40195ACQ38784992-6F940BC2-32EA-4BCD-A854-550A9091ED27Q38828883-BD327D5F-9570-4250-94B2-344FA5A1666DQ38938450-35AFE5F5-7988-427A-84D7-4986A39036DCQ39546057-7D4E83AF-8544-451F-A203-E70750C02E0DQ42120689-9CB17A5F-4753-4C13-B235-B0FC873E4176Q42626453-DF62A752-02D7-474F-AA42-F63784FE8B9EQ42725788-73240737-CA18-4ED6-AFF7-A92E3BBF2542Q45004022-AB488FE1-A8C5-43A6-BB7E-7E1E00759FCFQ46261737-831877BA-5335-4134-8CB5-54400F8ABD65Q46284091-833284C6-6CF0-4754-97A7-CA56803A4613Q46708553-0842A411-DA39-4C89-AFBD-7008E6B47985Q47128638-7BD67229-065B-4911-946D-4B7DB74A62D0Q47886547-D189236D-DEFD-4A1A-A69B-D9AC9F76DEF5Q52607218-122BD565-5E7B-4E12-B002-9173C0E225C9Q59126461-547F004E-D783-4AD5-AC59-21CD928A1196
P2860
Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction.
description
2012 nî lūn-bûn
@nan
2012 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի մարտին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@ast
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@en
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@nl
type
label
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@ast
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@en
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@nl
prefLabel
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@ast
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@en
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@nl
P2093
P50
P1476
Integration of pro-inflammator ...... c islet beta cell dysfunction.
@en
P2093
David J Maloney
Ganesha Rai
Jerry L Nadler
Jessica R Weaver
Theodore R Holman
P356
10.1016/J.MCE.2012.03.004
P577
2012-03-20T00:00:00Z