Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
about
New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressEffect of redox modulating NRF2 activators on chronic kidney diseaseOxidative stress and nucleic acid oxidation in patients with chronic kidney diseaseIdentification of Cys255 in HIF-1α as a novel site for development of covalent inhibitors of HIF-1α/ARNT PasB domain protein-protein interactionWhen NRF2 talks, who's listening?Nrf2 suppresses lupus nephritis through inhibition of oxidative injury and the NF-κB-mediated inflammatory responseThe complexity of the Nrf2 pathway: beyond the antioxidant responseSynthetic triterpenoids target the Arp2/3 complex and inhibit branched actin polymerization.High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Triterpenoids display single agent anti-tumor activity in a transgenic mouse model of chronic lymphocytic leukemia and small B cell lymphoma.Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-kappaB with antimyeloma activity in vitro and in vivo.Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index.N-acetylcysteine, reactive oxygen species and beyond.The triterpenoid CDDO-Me delays murine acute graft-versus-host disease with the preservation of graft-versus-tumor effects after allogeneic bone marrow transplantation.Determining Cysteines Available for Covalent Inhibition Across the Human Kinome.CDDO-Me, a synthetic triterpenoid, inhibits expression of IL-6 and Stat3 phosphorylation in multi-drug resistant ovarian cancer cells.Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implicationsProteomic analysis shows synthetic oleanane triterpenoid binds to mTORLipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.Induction of Apoptosis in Pancreatic Cancer Cells by CDDO-Me Involves Repression of Telomerase through Epigenetic Pathways.Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.The synthetic triterpenoid, CDDO-Me, modulates the proinflammatory response to in vivo lipopolysaccharide challenge.A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas.Modification of cysteine 179 of IkappaBalpha kinase by nimbolide leads to down-regulation of NF-kappaB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agentsBardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties.Radiation protection of the gastrointestinal tract and growth inhibition of prostate cancer xenografts by a single compound.Discontinued in 2013: diabetic drugs.Trichothecin induces cell death in NF-κB constitutively activated human cancer cells via inhibition of IKKβ phosphorylation.Triterpenoid CDDO-methyl ester inhibits the Janus-activated kinase-1 (JAK1)-->signal transducer and activator of transcription-3 (STAT3) pathway by direct inhibition of JAK1 and STAT3Bardoxolone methyl (BARD) ameliorates ischemic AKI and increases expression of protective genes Nrf2, PPARγ, and HO-1.Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinaseTargeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity.Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agentsOleanane triterpenoid CDDO-Me inhibits Akt activity without affecting PDK1 kinase or PP2A phosphatase activity in cancer cells.Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405.Therapeutic effects of C-28 methyl ester of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid (CDDO-Me; bardoxolone methyl) on radiation-induced lung inflammation and fibrosis in mice.Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stressThe mitochondrial ATP-dependent Lon protease: a novel target in lymphoma death mediated by the synthetic triterpenoid CDDO and its derivatives.
P2860
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P2860
Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.
description
2006 nî lūn-bûn
@nan
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@ast
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@en
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@nl
type
label
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@ast
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@en
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@nl
prefLabel
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@ast
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@en
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@nl
P2093
P2860
P356
P1476
Triterpenoid CDDO-Me blocks th ...... ibition of IKKbeta on Cys-179.
@en
P2093
Colin Meyer
Deepak Raina
Donald Kufe
Rehan Ahmad
Surender Kharbanda
P2860
P304
35764-35769
P356
10.1074/JBC.M607160200
P407
P577
2006-09-24T00:00:00Z