Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.
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Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347The cnidarian origin of the proto-oncogenes NF-κB/STAT and WNT-like oncogenic pathway drives the ctenophores (Review)Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activitiesNMR Structure of Carcinoscorpius rotundicauda Thioredoxin-related Protein 16 and Its Role in Regulating Transcription Factor NF- B ActivityIdentification of an NF-κB p50/p65-responsive site in the human MIR155HG promoter.Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation.GSK-3 represses growth factor-inducible genes by inhibiting NF-kappaB in quiescent cells.NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway.Modification of the cysteine residues in IkappaBalpha kinase and NF-kappaB (p65) by xanthohumol leads to suppression of NF-kappaB-regulated gene products and potentiation of apoptosis in leukemia cellsInhibiting NF-κB activation by small molecules as a therapeutic strategy.Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179.Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.The apoptogenic toxin AIP56 is a metalloprotease A-B toxin that cleaves NF-κb P65Withaferin A targets heat shock protein 90 in pancreatic cancer cells.3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in IκBα kinase, leading to down-regulation of nuclear factor-κB (NF-κB)-regulated gene products and sensitization of tumor cellsDimethyl Fumarate Inhibits the Nuclear Factor κB Pathway in Breast Cancer Cells by Covalent Modification of p65 ProteinNatural products: chemical instruments to apprehend biological symphony.Structure-activity relationship (SAR) of withanolides to inhibit Hsp90 for its activity in pancreatic cancer cells.Chemical biology of inflammatory cytokine signaling.Direct Rel/NF-κB inhibitors: structural basis for mechanism of action.NF-κB in colorectal cancer.Novel NF-κB inhibitors: a patent review (2011 - 2014).Inhibition of Oncogenic Transcription Factor REL by the Natural Product Derivative Calafianin Monomer 101 Induces Proliferation Arrest and Apoptosis in Human B-Lymphoma Cell Lines.Withaferin A and its potential role in glioblastoma (GBM).Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity.Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotBcl-XL, but not Bcl-2, can protect human B-lymphoma cell lines from parthenolide-induced apoptosisEpoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.Targeting IκappaB kinases for cancer therapy.Evaluation of the antioxidant, anti-inflammatory, and anticancer activities of Euphorbia hirta ethanolic extract.Withaferin A abolishes the stem cell factor-stimulated pigmentation of human epidermal equivalents by interrupting the auto-phosphorylation of c-KIT in human melanocytes.
P2860
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P2860
Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Inhibition of transcription fa ...... i-cancer cell growth activity.
@en
type
label
Inhibition of transcription fa ...... i-cancer cell growth activity.
@en
prefLabel
Inhibition of transcription fa ...... i-cancer cell growth activity.
@en
P2093
P1476
Inhibition of transcription fa ...... ti-cancer cell growth activity
@en
P2093
Diana Rosman
Emily A Pace
John A Porco
Sujata Bardhan
Thomas D Gilmore
P304
P356
10.1016/J.BCP.2005.11.013
P407
P577
2005-12-19T00:00:00Z