Molecular insights into aminoglycoside action and resistance.
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New developments in aminoglycoside therapy and ototoxicityMetabolite-enabled eradication of bacterial persisters by aminoglycosidesStructure and Functional Diversity of GCN5-Related N-Acetyltransferases (GNAT)Bacterial GCN5-Related N-Acetyltransferases: From Resistance to RegulationStrategies to overcome the action of aminoglycoside-modifying enzymes for treating resistant bacterial infectionsPre-disposition and epigenetics govern variation in bacterial survival upon stressKinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6‘- N -Acetyltransferase † , ‡Mechanistic and Structural Analysis of Aminoglycoside N -Acetyltransferase AAC(6′)-Ib and Its Bifunctional, Fluoroquinolone-Active AAC(6′)-Ib-cr Variant † ‡Engineering an allosteric binding site for aminoglycosides into TEM1-β-LactamaseInhibition of aminoglycoside-deactivating enzymes APH(3')-IIIa and AAC(6')-Ii by amphiphilic paromomycin O2''-ether analogues4′-O-substitutions determine selectivity of aminoglycoside antibioticsTargeting Antibiotic ResistanceParomomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible -resistant Leishmania donovaniEvaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic reviewOverexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosisCationic synthetic peptides: assessment of their antimicrobial potency in liquid preserved boar semenIn vivo selection of resistant E. coli after ingestion of milk with added drug residuesA novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.Ototoxicity in dogs and cats.Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes.Structural and energetic analysis of 2-aminobenzimidazole inhibitors in complex with the hepatitis C virus IRES RNA using molecular dynamics simulations.Classic reaction kinetics can explain complex patterns of antibiotic action.Two-dimensional combinatorial screening identifies specific 6'-acylated kanamycin A- and 6'-acylated neamine-RNA hairpin interactions.Recent developments in antibacterial drug discovery: microbe-derived natural products--from collection to the clinic.Characterization of moenomycin antibiotic complex by multistage MALDI-IT/RTOF-MS and ESI-IT-MS.Cationic polyamines inhibit anthrax lethal factor proteaseSmall molecule microarrays of RNA-focused peptoids help identify inhibitors of a pathogenic group I intronSearch for novel aminoglycosides by combining fragment-based virtual screening and 3D-QSAR scoringTwo-dimensional combinatorial screening and the RNA Privileged Space Predictor program efficiently identify aminoglycoside-RNA hairpin loop interactionsBinding of aminoglycoside antibiotics to helix 69 of 23S rRNANew trends in aminoglycosides use.Understanding the origins of bacterial resistance to aminoglycosides through molecular dynamics mutational study of the ribosomal A-site.Expansion of the aminoglycoside-resistance 16S rRNA (m(1)A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin.Thermostable hexameric form of Eis (Rv2416c) protein of M. tuberculosis plays an important role for enhanced intracellular survival within macrophagesMolecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa.Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.Engineering persister-specific antibiotics with synergistic antimicrobial functionsIdentification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics.Aminoglycoside modifying enzymes.
P2860
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P2860
Molecular insights into aminoglycoside action and resistance.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Molecular insights into aminoglycoside action and resistance.
@ast
Molecular insights into aminoglycoside action and resistance.
@en
type
label
Molecular insights into aminoglycoside action and resistance.
@ast
Molecular insights into aminoglycoside action and resistance.
@en
prefLabel
Molecular insights into aminoglycoside action and resistance.
@ast
Molecular insights into aminoglycoside action and resistance.
@en
P356
P1433
P1476
Molecular insights into aminoglycoside action and resistance.
@en
P2093
John S Blanchard
Sophie Magnet
P304
P356
10.1021/CR0301088
P577
2005-02-01T00:00:00Z