Function of the nucleotide exchange activity of vav1 in T cell development and activation.
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Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cellsInterchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular functionConcerning immune synapses: a spatiotemporal timelineGene targeting in mice: a reviewVav family exchange factors: an integrated regulatory and functional viewThe Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loopsTwo Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with VavSignaling by the phosphoinositide 3-kinase family in immune cellsMechanism and function of Vav1 localisation in TCR signalling.Tyrosine residues at the carboxyl terminus of Vav1 play an important role in regulation of its biological activity.Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic MiceCritical roles for Rac GTPases in T-cell migration to and within lymph nodes.Multimolecular analysis of stable immunological synapses reveals sustained recruitment and sequential assembly of signaling clustersVav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.Impairment of immunological synapse formation in adaptively tolerant T cellsThe p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell developmentVav1 oncogenic mutation inhibits T cell receptor-induced calcium mobilization through inhibition of phospholipase Cγ1 activationA Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation.Vav1 GEF activity is required for T cell mediated allograft rejectionPI3K signalling in B- and T-lymphocytes: new developments and therapeutic advancesSignaling for synergistic activation of natural killer cells.The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling.Lymphocyte signaling: beyond knockouts.Complementary phosphorylation sites in the adaptor protein SLP-76 promote synergistic activation of natural killer cellsVav1-mediated scaffolding interactions stabilize SLP-76 microclusters and contribute to antigen-dependent T cell responses.Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomasVav1 in hematologic neoplasms, a mini review.T cell antigen receptor activation and actin cytoskeleton remodeling.Rho-GTPases as key regulators of T lymphocyte biology.The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1.Themis1 enhances T cell receptor signaling during thymocyte development by promoting Vav1 activity and Grb2 stability.Opposing effects of actin signaling and LFA-1 on establishing the affinity threshold for inducing effector T-cell responses in mice.Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.Activation of RHOA-VAV1 signaling in angioimmunoblastic T-cell lymphoma.A Natural Variant of the Signaling Molecule Vav1 Enhances Susceptibility to Myasthenia Gravis and Influences the T Cell Receptor Repertoire
P2860
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P2860
Function of the nucleotide exchange activity of vav1 in T cell development and activation.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
Function of the nucleotide exc ...... ll development and activation.
@ast
Function of the nucleotide exc ...... ll development and activation.
@en
type
label
Function of the nucleotide exc ...... ll development and activation.
@ast
Function of the nucleotide exc ...... ll development and activation.
@en
prefLabel
Function of the nucleotide exc ...... ll development and activation.
@ast
Function of the nucleotide exc ...... ll development and activation.
@en
P2093
P2860
P1433
P1476
Function of the nucleotide exc ...... ll development and activation.
@en
P2093
Alexander Saveliev
Jonathan Rapley
Lesley Vanes
Olga Ksionda
Victor L J Tybulewicz
P2860
P356
10.1126/SCISIGNAL.2000420
P577
2009-12-15T00:00:00Z