Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation - Wikidata - awgldk - TriplyDB

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

http://www.wikidata.org/entity/Q22254031

about

A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization.The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis The PEA-15 protein regulates autophagy via activation of JNK TNF-stimulated MAP kinase activation mediated by a Rho family GTPase signaling pathway MLK3 Signaling in Cancer Invasion Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components.POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis.Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3.PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase.Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain.Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours.Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane.Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif.Mixed-lineage kinase control of JNK and p38 MAPK pathways.Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development.MLK4 has negative effect on TLR4 signaling.Cloning and Initial Functional Characterization of Mlk4α and Mlk4β PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation Lysine 63-linked ubiquitination modulates mixed lineage kinase-3 interaction with JIP1 scaffold protein in cytokine-induced pancreatic β cell death Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity?The interferon signaling network and transcription factor C/EBP-beta The small GTPase RALA controls c-Jun N-terminal kinase-mediated FOXO activation by regulation of a JIP1 scaffold complex Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer.Involvement of mixed lineage kinase 3 in cancer.Regulation of the protein stability of POSH and MLK family.Cdc42 and Rac1 are major contributors to the saturated fatty acid-stimulated JNK pathway in hepatocytes.Induced, selective proteolysis of MLK3 negatively regulates MLK3/JNK signalling.Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains.Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling.Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling.Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family.Mixed lineage kinase 3 mediates gp120IIIB-induced neurotoxicity.MLK3 phosphorylation by ERK1/2 is required for oxidative stress-induced invasion of colorectal cancer cells.

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Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

http://www.wikidata.org/entity/Q22254031

description

2000 nî lūn-bûn

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2000 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2000 թվականի մայիսին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Cdc42-induced activation of th ...... and changes in phosphorylation

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Journal of Biological Chemistry

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Cdc42-induced activation of th ...... and changes in phosphorylation

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P2860

Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK

The JIP group of mitogen-activated protein kinase scaffold proteins

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

The Cdc42/Rac interactive binding region motif of the Wiskott Aldrich syndrome protein (WASP) is necessary but not sufficient for tight binding to Cdc42 and structure formation

Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP

Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42

CDC42 and FGD1 cause distinct signaling and transforming activities.

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