Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
about
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillationDysfunctional ryanodine receptors in the heart: new insights into complex cardiovascular diseasesCounteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein PhosphatasesIon Channels in the HeartThe ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisisCaMKII oxidative activation and the pathogenesis of cardiac diseaseCalmodulin-dependent protein kinase II: linking heart failure and arrhythmiasMechanisms of altered Ca²⁺ handling in heart failureNew therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII)Calcium dysregulation in atrial fibrillation: the role of CaMKIICardiac ryanodine receptors control heart rate and rhythmicity in adult miceA β(IV)-spectrin/CaMKII signaling complex is essential for membrane excitability in miceCalmodulin binding proteins provide domains of local Ca2+ signaling in cardiac myocytesAxial tubule junctions control rapid calcium signaling in atriaRole of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease.Pitx2, an atrial fibrillation predisposition gene, directly regulates ion transport and intercalated disc genes.Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.Protein Kinases as Drug Development Targets for Heart Disease TherapyHeart-specific overexpression of CUGBP1 reproduces functional and molecular abnormalities of myotonic dystrophy type 1.Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillationIntracellular translocation of calmodulin and Ca2+/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes.Improved understanding of the pathophysiology of atrial fibrillation through the lens of discrete pathological pathwaysPitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specificationRyanodine receptors: structure, expression, molecular details, and function in calcium release.CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice.Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.Reduced junctional Na+/Ca2+-exchanger activity contributes to sarcoplasmic reticulum Ca2+ leak in junctophilin-2-deficient mice.Norepinephrine-Induced Adrenergic Activation Strikingly Increased the Atrial Fibrillation Duration through β1- and α1-Adrenergic Receptor-Mediated Signaling in Mice.The ryanodine receptor in cardiac physiology and disease.Acute atrial arrhythmogenicity and altered Ca(2+) homeostasis in murine RyR2-P2328S hearts.Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.Maternal diet-induced obesity programs cardiovascular dysfunction in adult male mouse offspring independent of current body weightEffects of CaMKII-mediated phosphorylation of ryanodine receptor type 2 on islet calcium handling, insulin secretion, and glucose toleranceOxidative stress and ca(2+) release events in mouse cardiomyocytesLoss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.
P2860
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P2860
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.
description
2009 nî lūn-bûn
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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
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2009年の論文
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2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
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2009年论文
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name
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@ast
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@en
type
label
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@ast
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@en
prefLabel
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@ast
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@en
P2093
P2860
P1476
Calmodulin kinase II-mediated ...... s atrial fibrillation in mice.
@en
P2093
Darlene G Skapura
Dobromir Dobrev
Frank Ulrich Müller
Marco Santonastasi
Mark E Anderson
Miguel Valderrábano
Mihail G Chelu
Ralph J van Oort
Satyam Sarma
P2860
P304
P407
P577
2009-07-01T00:00:00Z