Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
about
Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageComponents of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunctionMechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complexAlternative splicing controls nuclear translocation of the cell cycle-regulated Nek2 kinaseMitotic regulation by NIMA-related kinasesThe APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction.Gene copy number variation spanning 60 million years of human and primate evolutionK11-linked ubiquitin chains as novel regulators of cell divisionFunctional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisStructure and regulation of the human Nek2 centrosomal kinaseAnalysis of activator-binding sites on the APC/C supports a cooperative substrate-binding mechanism.Unique D box and KEN box sequences limit ubiquitination of Acm1 and promote pseudosubstrate inhibition of the anaphase-promoting complexSpatiotemporal regulation of the anaphase-promoting complex in mitosisCharacterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunctionBood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferaseThe APC/C recruits cyclin B1-Cdk1-Cks in prometaphase before D box recognition to control mitotic exitThe anaphase promoting complex/cyclosome: a machine designed to destroyStructure of the anaphase-promoting complex/cyclosome interacting with a mitotic checkpoint complex.Multiple mechanisms determine the order of APC/C substrate degradation in mitosis.Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.A role for Cdc2- and PP2A-mediated regulation of Emi2 in the maintenance of CSF arrest.Enhanced protein degradation by branched ubiquitin chains.Activation of the APC/C ubiquitin ligase by enhanced E2 efficiencyNek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.How cyclin A destruction escapes the spindle assembly checkpoint.Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thalianaAPC/C(Cdc20) targets E2F1 for degradation in prometaphase.Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal.Mes1 controls the meiosis I to meiosis II transition by distinctly regulating the anaphase-promoting complex/cyclosome coactivators Fzr1/Mfr1 and Slp1 in fission yeastThe biochemistry of mitosisPhosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.Targeting Cdc20 as a novel cancer therapeutic strategy.An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitinationThe APC/C Ubiquitin Ligase: From Cell Biology to TumorigenesisOSD1 promotes meiotic progression via APC/C inhibition and forms a regulatory network with TDM and CYCA1;2/TAM.Ubiquitination of Cdc20 by the APC occurs through an intramolecular mechanismState of the APC/C: organization, function, and structure.Substrate Recognition by the Cdh1 Destruction Box Receptor Is a General Requirement for APC/CCdh1-mediated ProteolysisCrystal structure of the N-terminal domain of anaphase-promoting complex subunit 7.
P2860
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P2860
Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C
description
2006 nî lūn-bûn
@nan
2006 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Early mitotic degradation of N ...... ent interaction with the APC/C
@ast
Early mitotic degradation of N ...... ent interaction with the APC/C
@en
Early mitotic degradation of N ...... ent interaction with the APC/C
@en-gb
Early mitotic degradation of N ...... ent interaction with the APC/C
@nl
type
label
Early mitotic degradation of N ...... ent interaction with the APC/C
@ast
Early mitotic degradation of N ...... ent interaction with the APC/C
@en
Early mitotic degradation of N ...... ent interaction with the APC/C
@en-gb
Early mitotic degradation of N ...... ent interaction with the APC/C
@nl
prefLabel
Early mitotic degradation of N ...... ent interaction with the APC/C
@ast
Early mitotic degradation of N ...... ent interaction with the APC/C
@en
Early mitotic degradation of N ...... ent interaction with the APC/C
@en-gb
Early mitotic degradation of N ...... ent interaction with the APC/C
@nl
P2093
P2860
P3181
P356
P1433
P1476
Early mitotic degradation of N ...... ent interaction with the APC/C
@en
P2093
Andrew M Fry
Guojie Mao
Hiroyuki Yamano
Michelle J Hayes
Samantha L Wattam
P2860
P2888
P304
P3181
P356
10.1038/NCB1410
P407
P577
2006-04-30T00:00:00Z
P5875
P6179
1052876573