Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
about
Human single-stranded DNA binding proteins are essential for maintaining genomic stabilityThe proteasomal de-ubiquitinating enzyme POH1 promotes the double-strand DNA break responseFBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51Tyrosine phosphorylation enhances RAD52-mediated annealing by modulating its DNA binding.Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forksFBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cellsDynamics of DNA damage response proteins at DNA breaks: a focus on protein modificationsInteractions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantumFunctions of Ubiquitin and SUMO in DNA Replication and Replication StressThe expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instabilitySources of DNA double-strand breaks and models of recombinational DNA repairConcentration-dependent exchange of replication protein A on single-stranded DNA revealed by single-molecule imagingBRG1 promotes the repair of DNA double-strand breaks by facilitating the replacement of RPA with RAD51.Using a Fragment-Based Approach To Target Protein-Protein InteractionsHigh-resolution structure of the presynaptic RAD51 filament on single-stranded DNA by electron cryo-microscopy.Engineering archeal surrogate systems for the development of protein-protein interaction inhibitors against human RAD51Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinicHomologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteinsMolding BRCA2 function through its interacting partnersA Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous RecombinationUnraveling the mechanism of BRCA2 in homologous recombinationRad52 inactivation is synthetically lethal with BRCA2 deficiencyInterrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinityEssential roles of BCCIP in mouse embryonic development and structural stability of chromosomesHomologs of breast cancer genes in plantsMicroRNAs Used in Combination with Anti-Cancer Treatments Can Enhance Therapy EfficacyRad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination.The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation.Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.Contributions of the RAD51 N-terminal domain to BRCA2-RAD51 interaction.RPA-Mediated Recruitment of the E3 Ligase RFWD3 Is Vital for Interstrand Crosslink Repair and Human Health.The homologous recombination protein RAD51D protects the genome from large deletionsFunctional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistanceA fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Recent Developments Using Small Molecules to Target RAD51: How to Best Modulate RAD51 for Anticancer Therapy?Interactive Roles of DNA Helicases and Translocases with the Single-Stranded DNA Binding Protein RPA in Nucleic Acid Metabolism.Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods.The epistatic relationship between BRCA2 and the other RAD51 mediators in homologous recombination.Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery.
P2860
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P2860
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@ast
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@en
type
label
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@ast
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@en
prefLabel
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@ast
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@en
P2093
P2860
P356
P1476
Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA.
@en
P2093
P2860
P2888
P304
P356
10.1038/NSMB.1904
P577
2010-08-22T00:00:00Z