Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
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PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADDProtein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionOn the Quest of Cellular Functions of PEA-15 and the Therapeutic OpportunitiesRecognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domainPEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastomaERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetes.Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Phosphoprotein enriched in astrocytes (PEA)-15: a potential therapeutic target in multiple disease states.Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancerDeath effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanismIdentification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells.Characterization of a MAPK scaffolding protein logic gate in gonadotropes.Cell fate decisions are specified by the dynamic ERK interactome.Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanismEstradiol attenuates down-regulation of PEA-15 and its two phosphorylated forms in ischemic brain injuryAbsence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo.Clozapine impairs insulin action by up-regulating Akt phosphorylation and Ped/Pea-15 protein abundance.PED/PEA-15 induces autophagy and mediates TGF-beta1 effect on muscle cell differentiationHigh ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patientsGlaucoma related Proteomic Alterations in Human Retina SamplesAn astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucomaPhosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoterMiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation.Delivery of intracellular-acting biologics in pro-apoptotic therapies.Regulations of Reversal of Senescence by PKC Isozymes in Response to 12-O-Tetradecanoylphorbol-13-Acetate via Nuclear Translocation of pErk1/2.Hyperglycemia aggravates decreases of PEA-15 and its two phosphorylated forms in cerebral ischemia.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.Proteomics analyses of human optic nerve head astrocytes following biomechanical strain.Chaperone-mediated autophagy substrate proteins in cancer.Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice.Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.Thioredoxin promotes survival signaling events under nitrosative/oxidative stress associated with cancer development.Circadian expression and functional characterization of PEA-15 within the mouse suprachiasmatic nucleus.
P2860
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P2860
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
description
1993 nî lūn-bûn
@nan
1993 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի մարտին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@ast
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@en
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@nl
type
label
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@ast
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@en
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@nl
prefLabel
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@ast
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@en
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@nl
P2093
P3181
P1476
Characterization of PEA-15, a major substrate for protein kinase C in astrocytes
@en
P2093
Chneiweiss H
Danziger N
Glowinski J
P304
P3181
P407
P577
1993-03-01T00:00:00Z