Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype - Wikidata - awgldk - TriplyDB

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

http://www.wikidata.org/entity/Q35893635

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A NIK-IKKα module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1 RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure Somatic cell type specific gene transfer reveals a tumor-promoting function for p21(Waf1/Cip1)Stem cells and cell therapies in lung biology and lung diseases p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling.p27(Kip1) controls cytokinesis via the regulation of citron kinase activation.p27Kip1 promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway.Familial isolated pituitary adenomas: from genetics to therapy.Characterization of a naturally-occurring p27 mutation predisposing to multiple endocrine tumors.Pheochromocytoma in rats with multiple endocrine neoplasia (MENX) shares gene expression patterns with human pheochromocytoma.AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.p27: a barometer of signaling deregulation and potential predictor of response to targeted therapies.Distinct expression pattern and post-transcriptional regulation of cell cycle genes in the glandular epithelia of avian ovarian carcinomas BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein.p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy.Pax6 is required for normal cell-cycle exit and the differentiation kinetics of retinal progenitor cells.Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.Epithelial-myoepithelial tumour of the lung: a case report referring to its molecular histogenesis.Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer.Development and neurogenic potential of Müller glial cells in the vertebrate retina.MENX and MEN4 Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation.p27Kip1 and p21Cip1 collaborate in the regulation of transcription by recruiting cyclin-Cdk complexes on the promoters of target genes.PCAF regulates the stability of the transcriptional regulator and cyclin-dependent kinase inhibitor p27 Kip1.Primary epithelial myoepithelial carcinoma of lung, reporting of a rare entity, its molecular histogenesis and review of the literature.A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation.TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma.Loss of p27Kip¹ promotes metaplasia in the pancreas via the regulation of Sox9 expression PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy.Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons.Cell cycle regulation in hair cell development and regeneration in the mouse cochlea.Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.The non-canonical functions of p27(Kip1) in normal and tumor biology.The CDK inhibitors: potential targets for therapeutic stem cell manipulations?Cancer stem cells and the ontogeny of lung cancer

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

http://www.wikidata.org/entity/Q35893635

description

2007 nî lūn-bûn

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年學術文章

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2007年學術文章

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2007年學術文章

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name

Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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type

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Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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prefLabel

Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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Genes & Development

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Discovery of an oncogenic acti ...... and a multiple tumor phenotype

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Arnaud Besson

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Bruce E Clurman

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Dianna Johnson

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Harry C Hwang

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James M Roberts

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Mark Gurian-West

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Michael A Dyer

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Samantha Cicero

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Stacy L Donovan

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P2860

Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans

CDK inhibitors: positive and negative regulators of G1-phase progression

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti

p18Ink4c collaborates with Men1 to constrain lung stem cell expansion and suppress non-small-cell lung cancers

Ocular retardation mouse caused by Chx10 homeobox null allele: impaired retinal progenitor proliferation and bipolar cell differentiation

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1731-1746

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10.1101/GAD.1556607

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14

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21

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2007-07-12T00:00:00Z

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6210982

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17626791

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1920168

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