Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
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A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptorsA novel mutation (Gln266-->His) in the alpha 1 subunit of the inhibitory glycine-receptor gene (GLRA1) in hereditary hyperekplexiaGenetic neurological channelopathies: molecular genetics and clinical phenotypes.The impact of human hyperekplexia mutations on glycine receptor structure and functionA Change in the Ion Selectivity of Ligand-Gated Ion Channels Provides a Mechanism to Switch BehaviorHyperekplexia in neonatesActivation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABAIdentification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channelLow level expression of glycine receptor beta subunit transgene is sufficient for phenotype correction in spastic miceTransient neuromotor phenotype in transgenic spastic mice expressing low levels of glycine receptor beta-subunit: an animal model of startle disease.Predicted structure of the extracellular region of ligand-gated ion-channel receptors shows SH2-like and SH3-like domains forming the ligand-binding siteGlycine receptor mouse mutants: model systems for human hyperekplexia4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors.Glycine receptor mutants of the mouse: what are possible routes of inhibitory compensation?Pore conformations and gating mechanism of a Cys-loop receptor.Cation permeability and cation-anion interactions in a mutant GABA-gated chloride channel from Drosophila.M2 pore mutations convert the glycine receptor channel from being anion- to cation-selective.Homology model of the GABAA receptor examined using Brownian dynamicsTheoretical studies of the M2 transmembrane segment of the glycine receptor: models of the open pore structure and current-voltage characteristics.Correlating structural and energetic changes in glycine receptor activation.Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin.Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.Potentiation of chloride responses to glycine by three 5-HT3 antagonists in rat spinal neuronesFunction of hyperekplexia-causing α1R271Q/L glycine receptors is restored by shifting the affected residue out of the allosteric signalling pathwayFixation of allosteric states of the nicotinic acetylcholine receptor by chemical cross-linking.Inhibitory glycine receptors: an update.Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules boundSingle channel analysis of conductance and rectification in cation-selective, mutant glycine receptor channelsCation-selective mutations in the M2 domain of the inhibitory glycine receptor channel reveal determinants of ion-charge selectivity.Rapid chemical kinetic techniques for investigations of neurotransmitter receptors expressed in Xenopus oocytesNew hyperekplexia mutations provide insight into glycine receptor assembly, trafficking, and activation mechanisms.Analysis of hyperekplexia mutations identifies transmembrane domain rearrangements that mediate glycine receptor activation.Propofol modulation of α1 glycine receptors does not require a structural transition at adjacent subunits that is crucial to agonist-induced activationA single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.What single-channel analysis tells us of the activation mechanism of ligand-gated channels: the case of the glycine receptor.Altered Channel Conductance States and Gating of GABAA Receptors by a Pore Mutation Linked to Dravet Syndrome.The multiple phenotypes of allosteric receptor mutants.Synaptic neurotransmitter-gated receptorsChloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents.Investigation of the alpha(1)-glycine receptor channel-opening kinetics in the submillisecond time domain.
P2860
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P2860
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia
description
1994 nî lūn-bûn
@nan
1994 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Decreased agonist affinity and ...... human hereditary hyperekplexia
@ast
Decreased agonist affinity and ...... human hereditary hyperekplexia
@en
Decreased agonist affinity and ...... human hereditary hyperekplexia
@nl
type
label
Decreased agonist affinity and ...... human hereditary hyperekplexia
@ast
Decreased agonist affinity and ...... human hereditary hyperekplexia
@en
Decreased agonist affinity and ...... human hereditary hyperekplexia
@nl
prefLabel
Decreased agonist affinity and ...... human hereditary hyperekplexia
@ast
Decreased agonist affinity and ...... human hereditary hyperekplexia
@en
Decreased agonist affinity and ...... human hereditary hyperekplexia
@nl
P2093
P2860
P1433
P1476
Decreased agonist affinity and ...... human hereditary hyperekplexia
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1994.TB06742.X
P407
P577
1994-09-01T00:00:00Z