Distinct agonist- and antagonist-binding sites on the glycine receptor
about
Decreased agonist affinity and chloride conductance of mutant glycine receptors associated with human hereditary hyperekplexia5-HT3 receptorsKinetic determinants of agonist action at the recombinant human glycine receptorDifferential agonist sensitivity of glycine receptor alpha2 subunit splice variantsExtrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptorsGlycine receptor mechanism elucidated by electron cryo-microscopy.The human glycine receptor subunit alpha3. Glra3 gene structure, chromosomal localization, and functional characterization of alternative transcriptsPrinciples of agonist recognition in Cys-loop receptorsMicroscopic kinetics and energetics distinguish GABA(A) receptor agonists from antagonists.Point mutation of glycine receptor alpha 1 subunit in the spasmodic mouse affects agonist responsesIdentification of amino acid residues responsible for the alpha5 subunit binding selectivity of L-655,708, a benzodiazepine binding site ligand at the GABA(A) receptor.Molecular determinants of proton modulation of glycine receptors.A cation-π interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists.Potentiation of chloride responses to glycine by three 5-HT3 antagonists in rat spinal neuronesEnhancement of homomeric glycine receptor function by long-chain alcohols and anaestheticsA cation-pi interaction in the binding site of the glycine receptor is mediated by a phenylalanine residue.Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domainThe unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element.Tropisetron modulation of the glycine receptor: femtomolar potentiation and a molecular determinant of inhibition.Prediction of 5-HT3 receptor agonist-binding residues using homology modeling.Locating an antagonist in the 5-HT3 receptor binding site using modeling and radioligand binding.The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.Selective antagonism of rat inhibitory glycine receptor subunits.The inhibitory glycine receptor. A candidate protein of signal transduction in neuroendocrine tissue.The inhibitory neuronal glycine receptor.Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine.Ivermectin, an unconventional agonist of the glycine receptor chloride channel.Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors.Baculovirus-driven expression and purification of glycine receptor alpha 1 homo-oligomers.Actions of 3-[2-phosphonomethyl[1,1-biphenyl]-3-yl]alanine (PMBA) on cloned glycine receptors.Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.Putative glycine receptors in Hydra: a biochemical and behavioural study.A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor.Cloning and functional characterization of two glycine receptor alpha-subunits from the perch retina.Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism.Mechanisms of H+ modulation of glycinergic response in rat sacral dorsal commissural neurons.Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.Cultured oligodendrocyte progenitors derived from cerebral cortex express a glycine receptor which is pharmacologically distinct from the neuronal isoform.
P2860
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P2860
Distinct agonist- and antagonist-binding sites on the glycine receptor
description
1992 nî lūn-bûn
@nan
1992 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
Distinct agonist- and antagonist-binding sites on the glycine receptor
@ast
Distinct agonist- and antagonist-binding sites on the glycine receptor
@en
Distinct agonist- and antagonist-binding sites on the glycine receptor
@nl
type
label
Distinct agonist- and antagonist-binding sites on the glycine receptor
@ast
Distinct agonist- and antagonist-binding sites on the glycine receptor
@en
Distinct agonist- and antagonist-binding sites on the glycine receptor
@nl
prefLabel
Distinct agonist- and antagonist-binding sites on the glycine receptor
@ast
Distinct agonist- and antagonist-binding sites on the glycine receptor
@en
Distinct agonist- and antagonist-binding sites on the glycine receptor
@nl
P2093
P1433
P1476
Distinct agonist- and antagonist-binding sites on the glycine receptor
@en
P2093
C A Handford
P R Schofield
R J Vandenberg
P356
10.1016/0896-6273(92)90186-H
P407
P577
1992-09-01T00:00:00Z