IKK1-deficient mice exhibit abnormal development of skin and skeleton - Wikidata - awgldk - TriplyDB

IKK1-deficient mice exhibit abnormal development of skin and skeleton

IKK1-deficient mice exhibit abnormal development of skin and skeleton

http://www.wikidata.org/entity/Q24604269

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Functional isoforms of IkappaB kinase alpha (IKKalpha) lacking leucine zipper and helix-loop-helix domains reveal that IKKalpha and IKKbeta have different activation requirements Analysis of domains in the IKKalpha and IKKbeta proteins that regulate their kinase activity CIKS, a connection to Ikappa B kinase and stress-activated protein kinase Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes CSN3 interacts with IKKgamma and inhibits TNF- but not IL-1-induced NF-kappaB activation The tyrosine kinase Syk regulates TPL2 activation signals Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity Dlx genes, p63, and ectodermal dysplasias.The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex A novel role of IKKalpha in the mediation of UVB-induced G0/G1 cell cycle arrest response by suppressing Cyclin D1 expression Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK)IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas Kaposi's sarcoma associated herpes virus-encoded viral FLICE inhibitory protein activates transcription from HIV-1 Long Terminal Repeat via the classical NF-kappaB pathway and functionally cooperates with Tat Pathophysiology of osteoarthritis: canonical NF-κB/IKKβ-dependent and kinase-independent effects of IKKα in cartilage degradation and chondrocyte differentiation Molecular basis of cleft palates in mice NF-κB, the first quarter-century: remarkable progress and outstanding questions Palatogenesis and cutaneous repair: A two-headed coin Modeling AEC-New approaches to study rare genetic disorders Beyond NF-κB activation: nuclear functions of IκB kinase α The anatomical distribution of genetic associations.Increased IKKα expression in the basal layer of the epidermis of transgenic mice enhances the malignant potential of skin tumors NF-κB Pathways in the Pathogenesis of Multiple Sclerosis and the Therapeutic Implications Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation NAK is an IkappaB kinase-activating kinase Role of IKKgamma/nemo in assembly of the Ikappa B kinase complex Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium Regulation of beta-catenin function by the IkappaB kinases Fanconi anemia protein complex is a novel target of the IKK signalsome IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch NF-kappaB is essential for induction of CYLD, the negative regulator of NF-kappaB: evidence for a novel inducible autoregulatory feedback pathway

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P2860

IKK1-deficient mice exhibit abnormal development of skin and skeleton

http://www.wikidata.org/entity/Q24604269

description

1999 nî lūn-bûn

@nan

1999 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի մայիսին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

@wuu

name

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@ast

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@en

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@nl

type

label

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@ast

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@en

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@nl

prefLabel

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@ast

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@en

IKK1-deficient mice exhibit abnormal development of skin and skeleton

@nl

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Genes & Development

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IKK1-deficient mice exhibit abnormal development of skin and skeleton

@en

P2093

D Büscher

http://www.w3.org/2001/XMLSchema#string

I M Verma

http://www.w3.org/2001/XMLSchema#string

J C Izpisua-Belmonte

http://www.w3.org/2001/XMLSchema#string

J Y Hwang

http://www.w3.org/2001/XMLSchema#string

K F Lee

http://www.w3.org/2001/XMLSchema#string

Q Li

http://www.w3.org/2001/XMLSchema#string

Q Lu

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P2860

IKAP is a scaffold protein of the IkappaB kinase complex

IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

IkappaB kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex

MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta

Identification and characterization of an IkappaB kinase

The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate

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10.1101/GAD.13.10.1322

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10

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13

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10346820

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316728

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