Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers - Wikidata - awgldk - TriplyDB

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

http://www.wikidata.org/entity/Q24620397

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HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment Breast Cancer-Associated Fibroblasts: Where We Are and Where We Need to Go Lesser-Known Molecules in Ovarian Carcinogenesis Adipose tissue and adipocytes support tumorigenesis and metastasis Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery Understanding the Warburg effect and the prognostic value of stromal caveolin-1 as a marker of a lethal tumor microenvironment Role of oxidative stress and the microenvironment in breast cancer development and progression Anti-inflammatory/antioxidant use in long-term maintenance cancer therapy: a new therapeutic approach to disease progression and recurrence Caveolin-1: an essential modulator of cancer cell radio-and chemoresistance Ethanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer prevention Weak stromal Caveolin-1 expression in colorectal liver metastases predicts poor prognosis after hepatectomy for liver-only colorectal metastases.Caveolin-1: An Oxidative Stress-Related Target for Cancer Prevention.Loss of stromal caveolin-1 expression: a novel tumor microenvironment biomarker that can predict poor clinical outcomes for pancreatic cancer.Molecular profiling of a lethal tumor microenvironment, as defined by stromal caveolin-1 status in breast cancers.Mitochondrial oxidative stress drives tumor progression and metastasis: should we use antioxidants as a key component of cancer treatment and prevention?Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect: implications for PET imaging of human tumors Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts Stromal-epithelial metabolic coupling in cancer: integrating autophagy and metabolism in the tumor microenvironment.Loss of stromal caveolin-1 expression in colorectal cancer predicts poor survival Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts.Cytokine production and inflammation drive autophagy in the tumor microenvironment: role of stromal caveolin-1 as a key regulator.Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis.Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells.Monocarboxylate transporter 1 inhibitors as potential anticancer agents Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue.Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis Using the "reverse Warburg effect" to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers.Mitochondrial metabolism in cancer metastasis: visualizing tumor cell mitochondria and the "reverse Warburg effect" in positive lymph node tissue.Tumor-stroma relationships: who's the driver?Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production Caveolin-1 and accelerated host aging in the breast tumor microenvironment: chemoprevention with rapamycin, an mTOR inhibitor and anti-aging drug Downregulation of caveolin‑1 upregulates the expression of growth factors and regulators in co‑culture of fibroblasts with cancer cells

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Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers

http://www.wikidata.org/entity/Q24620397

description

2010 nî lūn-bûn

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2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2010 թվականի հուլիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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type

label

Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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prefLabel

Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

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Cancer Biology and Therapy

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Loss of stromal caveolin-1 exp ...... and basal-like breast cancers

@en

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Abhijit Dasgupta

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Agnieszka K Witkiewicz

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Edith P Mitchell

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Fran Guiles

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Jonathan R Brody

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Magdalena B Potoczek

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Ozlem Er

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Sara Sammons

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P2860

An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers

Molecular portraits of human breast tumours

Stromal caveolin-1 levels predict early DCIS progression to invasive breast cancer

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up

Reduction of caveolin and caveolae in oncogenically transformed cells

The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma.

Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers.

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors.

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135-43

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scholarly article

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10.4161/CBT.10.2.11983

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2

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10

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Michael P. Lisanti

Federica Sotgia

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2010-07-15T00:00:00Z

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20431349

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3040896

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