Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
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Chinese Herbs Interfering with Cancer Reprogramming MetabolismAutophagy in stem cells.Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discoveryRole of oxidative stress and the microenvironment in breast cancer development and progressionTherapeutic targeting of replicative immortalityEthanol exposure induces the cancer-associated fibroblast phenotype and lethal tumor metabolism: implications for breast cancer preventionMitochondria and cancerInteractions between exosomes from breast cancer cells and primary mammary epithelial cells leads to generation of reactive oxygen species which induce DNA damage response, stabilization of p53 and autophagy in epithelial cells.Marine Mollusk-Derived Agents with Antiproliferative Activity as Promising Anticancer Agents to Overcome Chemotherapy Resistance.The footprint of the ageing stroma in older patients with breast cancer.The nutritional phenome of EMT-induced cancer stem-like cellsThe ING1a tumor suppressor regulates endocytosis to induce cellular senescence via the Rb-E2F pathway.Pseudolaric acid B induced cell cycle arrest, autophagy and senescence in murine fibrosarcoma l929 cell.New targeted therapies for breast cancer: A focus on tumor microenvironmental signals and chemoresistant breast cancersAutophagy regulates colistin-induced apoptosis in PC-12 cells.The role of autophagy induced by tumor microenvironment in different cells and stages of cancerChemotherapy induces the cancer-associated fibroblast phenotype, activating paracrine Hedgehog-GLI signalling in breast cancer cellsCellular senescence and autophagy of myoepithelial cells are involved in the progression of in situ areas of carcinoma ex-pleomorphic adenoma to invasive carcinoma. An in vitro modelTumor suppression by p53 without apoptosis and senescence: conundrum or rapalog-like gerosuppression?CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.Hypoxia and gerosuppression: the mTOR saga continuesMacroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacyBroad targeting of resistance to apoptosis in cancer.Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cellsMitochondrial dysfunction in breast cancer cells prevents tumor growth: understanding chemoprevention with metformin.Selection of p53-Deficient Stromal Cells in the Tumor MicroenvironmentCigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.Autophagy is involved in TGF-β1-induced protective mechanisms and formation of cancer-associated fibroblasts phenotype in tumor microenvironmentCompartment-specific activation of PPARγ governs breast cancer tumor growth, via metabolic reprogramming and symbiosis.Impact of tumor microenvironment and epithelial phenotypes on metabolism in breast cancerRole of autophagy in the regulation of epithelial cell junctionsMesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.Oncogenes and inflammation rewire host energy metabolism in the tumor microenvironment: RAS and NFκB target stromal MCT4.Dysregulation of the mTOR pathway in p53-deficient mice.miR-31 affects colorectal cancer cells by inhibiting autophagy in cancer-associated fibroblasts.Heterotypic paracrine signaling drives fibroblast senescence and tumor progression of large cell carcinoma of the lung.Cancer-associated Fibroblasts Promote Irradiated Cancer Cell Recovery Through Autophagy.Autophagy and the Cell Cycle: A Complex Landscape.Tumour suppressor gene function in carcinoma-associated fibroblasts: from tumour cells via EMT and back again?
P2860
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P2860
Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis via glycolysis and ketone production
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Autophagy and senescence in ca ...... ycolysis and ketone production
@ast
Autophagy and senescence in ca ...... ycolysis and ketone production
@en
type
label
Autophagy and senescence in ca ...... ycolysis and ketone production
@ast
Autophagy and senescence in ca ...... ycolysis and ketone production
@en
prefLabel
Autophagy and senescence in ca ...... ycolysis and ketone production
@ast
Autophagy and senescence in ca ...... ycolysis and ketone production
@en
P2093
P2860
P50
P356
P1433
P1476
Autophagy and senescence in ca ...... ycolysis and ketone production
@en
P2093
Allison F Goldberg
Claudia Capparelli
Renee Balliet
Richard G Pestell
Timothy G Pestell
P2860
P304
P356
10.4161/CC.20718
P50
P577
2012-06-15T00:00:00Z