The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site
about
The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf.A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPasesRaf family kinases: old dogs have learned new tricksCrucial structural role for the PH and C1 domains of the Vav1 exchange factorThe RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activationSerine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activationCritical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformationS338 phosphorylation of Raf-1 is independent of phosphatidylinositol 3-kinase and Pak3Isoform-specific localization of A-RAF in mitochondriaThe strength of interaction at the Raf cysteine-rich domain is a critical determinant of response of Raf to Ras family small GTPasesAutoregulation of the Raf-1 serine/threonine kinaseRetinol as electron carrier in redox signaling, a new frontier in vitamin A researchStructural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae.Regulation of Raf through phosphorylation and N terminus-C terminus interactionProtein phosphatases 1 and 2A promote Raf-1 activation by regulating 14-3-3 interactionsCoassociation of Rap1A and Ha-Ras with Raf-1 N-terminal region interferes with ras-dependent activation of Raf-1Amphitropic proteins: regulation by reversible membrane interactions (review).Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα.Mammalian Raf-1 is activated by mutations that restore Raf signaling in DrosophilaStructural determinants of Ras-Raf interaction analyzed in live cells.Interactions of protein kinase C-α C1A and C1B domains with membranes: a combined computational and experimental study.Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Treble clef finger--a functionally diverse zinc-binding structural motifActivation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.Raf kinases: function, regulation and role in human cancer.Taxonomy and function of C1 protein kinase C homology domains.The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors.An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ.KSR stimulates Raf-1 activity in a kinase-independent manner.Reconstitution of modular PDK1 functions on trans-splicing of the regulatory PH and catalytic kinase domainsStructural Basis for the Failure of the C1 Domain of Ras Guanine Nucleotide Releasing Protein 2 (RasGRP2) to Bind Phorbol Ester with High Affinity.Selective Raf inhibition in cancer therapy.Protein kinase C: the "masters" of calcium and lipid.Tumor adaptation and resistance to RAF inhibitors.Activation kinetics of RAF protein in the ternary complex of RAF, RAS-GTP, and kinase on the plasma membrane of living cells: single-molecule imaging analysis.Vitamin A as PKC Co-factor and Regulator of Mitochondrial Energetics.Baculovirus-mediated expression of Plasmodium falciparum erythrocyte binding antigen 175 polypeptides and their recognition by human antibodies.Differential membrane binding and diacylglycerol recognition by C1 domains of RasGRPs.
P2860
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P2860
The solution structure of the Raf-1 cysteine-rich domain: a novel ras and phospholipid binding site
description
1996 nî lūn-bûn
@nan
1996 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The solution structure of the ...... and phospholipid binding site
@ast
The solution structure of the ...... and phospholipid binding site
@en
The solution structure of the ...... and phospholipid binding site
@nl
type
label
The solution structure of the ...... and phospholipid binding site
@ast
The solution structure of the ...... and phospholipid binding site
@en
The solution structure of the ...... and phospholipid binding site
@nl
prefLabel
The solution structure of the ...... and phospholipid binding site
@ast
The solution structure of the ...... and phospholipid binding site
@en
The solution structure of the ...... and phospholipid binding site
@nl
P2093
P2860
P356
P1476
The solution structure of the ...... and phospholipid binding site
@en
P2093
P2860
P304
P356
10.1073/PNAS.93.16.8312
P407
P577
1996-08-01T00:00:00Z