Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120. - Wikidata - awgldk - TriplyDB

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

http://www.wikidata.org/entity/Q36824891

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Conformational Masking and Receptor-Dependent Unmasking of Highly Conserved Env Epitopes Recognized by Non-Neutralizing Antibodies That Mediate Potent ADCC against HIV-1 Finding a better path to drug selectivity Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Two HIV-1 variants resistant to small molecule CCR5 inhibitors differ in how they use CCR5 for entry An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors Ligand binding analysis and screening by chemical denaturation shift Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.Induction of a Tier-1-like Phenotype in Diverse Tier-2 Isolates by Agents that Guide HIV-1 Env to Perturbation-sensitive, Non-native States.Use of the quartz crystal microbalance to monitor ligand-induced conformational rearrangements in HIV-1 envelope protein gp120.Soluble CD4 and CD4-mimetic compounds inhibit HIV-1 infection by induction of a short-lived activated state.Naturally occurring variability in the envelope glycoprotein of HIV-1 and development of cell entry inhibitors.CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.Enhanced exposure of human immunodeficiency virus type 1 primary isolate neutralization epitopes through binding of CD4 mimetic compounds.Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study.Structural determinants for affinity enhancement of a dual antagonist peptide entry inhibitor of human immunodeficiency virus type-1.CD4-induced activation in a soluble HIV-1 Env trimer.The active core in a triazole peptide dual-site antagonist of HIV-1 gp120.Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening Some binding-related drug properties are dependent on thermodynamic signature.Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18 Enhanced dynamics of HIV gp120 glycoprotein by small molecule binding Engineering and exploitation of a fluorescent HIV-1 gp120 for live cell CD4 binding assays Peptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition.Thermodynamics-based drug design: strategies for inhibiting protein-protein interactions.CD4 mimetics sensitize HIV-1-infected cells to ADCC.Liposomes for HIV prophylaxis.Functional Mimetics of the HIV-1 CCR5 Co-Receptor Displayed on the Surface of Magnetic Liposomes.Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.Small-Molecule CD4 Mimics Containing Mono-cyclohexyl Moieties as HIV Entry Inhibitors.Design, synthesis, and antiviral activity of entry inhibitors that target the CD4-binding site of HIV-1.Spontaneous rearrangement of the β20/β21 strands in simulations of unliganded HIV-1 glycoprotein, gp120 Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity.Fluctuation dynamics analysis of gp120 envelope protein reveals a topologically based communication network.Monoclonal antibody m18 paratope leading to dual receptor antagonism of HIV-1 gp120.Optimization of CD4/gp120 inhibitors by thermodynamic-guided alanine-scanning mutagenesis

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P2860

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

http://www.wikidata.org/entity/Q36824891

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

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type

label

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

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prefLabel

Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

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Thermodynamics of binding of a low-molecular-weight CD4 mimetic to HIV-1 gp120.

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P2093

Amos B Smith

http://www.w3.org/2001/XMLSchema#string

Amy Hubicki

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Arne Schön

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Danny Ng

http://www.w3.org/2001/XMLSchema#string

Ernesto Freire

http://www.w3.org/2001/XMLSchema#string

Jeffrey C Klein

http://www.w3.org/2001/XMLSchema#string

Navid Madani

http://www.w3.org/2001/XMLSchema#string

Xinzhen Yang

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P2860

Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

Identification of a major co-receptor for primary isolates of HIV-1

Energetics of the HIV gp120-CD4 binding reaction

Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

Core structure of gp41 from the HIV envelope glycoprotein

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors

Interactions of HIV-1 proteins gp120 and Nef with cellular partners define a novel allosteric paradigm

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10973-10980

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scholarly article

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10.1021/BI061193R

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36

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45

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Joseph Sodroski

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2006-09-01T00:00:00Z

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6835764

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16953583

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2504686

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