Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
about
The role of histone demethylases in cancer therapyKDM1 class flavin-dependent protein lysine demethylasesLSD1 inhibition: a therapeutic strategy in cancer?Histone Demethylases in Colon Cancer.CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.Lysine-Specific Demethylase 1A (KDM1A/LSD1): Product Recognition and Kinetic Analysis of Full-Length Histones.Epigenetic regulation of LSD1 during mammary carcinogenesis.Effects of the monoamine oxidase inhibitors pargyline and tranylcypromine on cellular proliferation in human prostate cancer cells.LSD1 engages a corepressor complex for the activation of the estrogen receptor α by estrogen and cAMPTriazole-dithiocarbamate based selective lysine specific demethylase 1 (LSD1) inactivators inhibit gastric cancer cell growth, invasion, and migration.The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.Context-specific regulation of cancer epigenomes by histone and transcription factor methylation.KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease.Medicinal chemistry insights in the discovery of novel LSD1 inhibitors.TCPs: privileged scaffolds for identifying potent LSD1 inhibitors for cancer therapy.Insight into the binding mode of a novel LSD1 inhibitor by molecular docking and molecular dynamics simulations.Histone Lysine Demethylase Inhibitors.Cellular analysis of the action of epigenetic drugs and probes.LSD1-mediated epigenetic modification contributes to proliferation and metastasis of colon cancer.Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.A comprehensive review of lysine-specific demethylase 1 and its roles in cancer.ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.A selective phenelzine analogue inhibitor of histone demethylase LSD1.LSD1 activation promotes inducible EMT programs and modulates the tumour microenvironment in breast cancer.Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.
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P2860
Lysine-specific histone demethylase 1 inhibitors control breast cancer proliferation in ERα-dependent and -independent manners.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Lysine-specific histone demeth ...... dent and -independent manners.
@ast
Lysine-specific histone demeth ...... dent and -independent manners.
@en
type
label
Lysine-specific histone demeth ...... dent and -independent manners.
@ast
Lysine-specific histone demeth ...... dent and -independent manners.
@en
prefLabel
Lysine-specific histone demeth ...... dent and -independent manners.
@ast
Lysine-specific histone demeth ...... dent and -independent manners.
@en
P2093
P2860
P356
P1433
P1476
Lysine-specific histone demeth ...... ndent and -independent manners
@en
P2093
Dewey G McCafferty
Donald P McDonnell
Jeff S Jasper
Michelle D Larrea
P2860
P304
P356
10.1021/CB300108C
P577
2012-05-10T00:00:00Z