Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939 - Wikidata - awgldk - TriplyDB

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

http://www.wikidata.org/entity/Q27676990

about

Wnt/beta-catenin signaling and small molecule inhibitors The 1.8 A Cholix Toxin Crystal Structure in Complex with NAD+ and Evidence for a New Kinetic Model Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors Evidence for tankyrases as antineoplastic targets in lung cancer.Identification of poly(ADP-ribose) polymerase-1 as a cell cycle regulator through modulating Sp1 mediated transcription in human hepatoma cells.Scaffold hopping approach on the route to selective tankyrase inhibitors.Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.Structural Implications for Selective Targeting of PARPs.PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.PARP inhibitors in cancer therapy: an update.Structural biology of the writers, readers, and erasers in mono- and poly(ADP-ribose) mediated signaling.PARP inhibitors: polypharmacology versus selective inhibition.Tankyrases as drug targets.Tankyrases: structure, function and therapeutic implications in cancer.Recent advances in the structure-based rational design of TNKSIs.A comprehensive look of poly(ADP-ribose) polymerase inhibition strategies and future directions for cancer therapy.Molecular regulation and pharmacological targeting of the β-catenin destruction complex.Exclusive destruction of mitotic spindles in human cancer cells.Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding.SEC-TID: A Label-Free Method for Small-Molecule Target Identification.Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors.The binding mechanism of a novel nicotinamide isostere inhibiting with TNKSs: a molecular dynamic simulation and binding free energy calculation.

P2860

Q24597197-58BC5783-671E-43D0-B58A-0FF2D71ACCCE Q27678743-B56D5791-61FB-4ED7-8130-7A46D745F10F Q27684215-CCE16A6F-C7FE-41DD-A4FD-A2B9D0550E2B Q34690600-AC655D1F-DB54-4284-9C1C-4D5AD7A67A00 Q35075466-E198622E-C0F3-4166-80CD-113687C4F209 Q35557026-6B06BE62-8F2B-4597-BC1F-A87F8E90C82E Q35869295-081E9215-3E7F-401E-95EF-F972F92AC5D3 Q37405386-1F314220-A076-463E-AFB9-036F1AB363D0 Q38075305-2D9DE06E-62DF-45B4-9608-CA2CE5B02A5B Q38078993-E1BB47E0-D889-463C-9C18-A9A613FEE03F Q38086332-745168CD-0D2D-4949-869B-44F6031D60E0 Q38100299-91D5A595-2708-4263-936F-4609DE23463B Q38104494-C5BA913F-D8A9-40C5-BE21-615A660DDBB2 Q38224266-7549BE68-5D35-4849-B958-02DD57206DB8 Q38248320-613BB6D0-CC6C-4629-937D-D3D25E076290 Q38780396-5B6ED09F-2614-4AA3-8ECB-E22B98ECD0C2 Q39387545-737FCEC4-E7BC-4D6A-8401-CB663AEFAD96 Q42290806-3DA0801D-31C5-46CD-8DEF-68750FF70CC8 Q47131999-F003CC1C-483D-4D7E-8775-3CFB6A2C64E5 Q48019814-D90A295D-62CA-4106-9FA8-2CBE9DA341E1 Q48129205-B083CAC8-6EC3-4C4D-81CD-5CA2BBD5B5C7 Q50921784-B9082DA4-C8C7-43CE-97B8-B16915A3B231

P2860

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

http://www.wikidata.org/entity/Q27676990

description

2012 nî lūn-bûn

@nan

2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2012 թվականի փետրվարին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年学术文章

@wuu

2012年学术文章

@zh-cn

2012年学术文章

@zh-hans

2012年学术文章

@zh-my

2012年学术文章

@zh-sg

2012年學術文章

@yue

name

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@ast

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@en

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@nl

type

label

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@ast

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@en

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@nl

prefLabel

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@ast

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@en

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@nl

P1433

Q27676990-95687832-4045-42CE-866A-F4CBC4EB9727

P1476

Q27676990-D23E14DD-814B-42F1-A907-48F3F86C4B0C

P2093

Q27676990-1DB27912-CBE6-4A10-81BD-C5AD769684DD

Q27676990-2451EDB4-EFEE-48BF-BD62-A93CB24494D5

Q27676990-70BB1867-33EC-4C13-A8A2-30168030DA99

Q27676990-9554006D-AF59-44A6-AD8E-12807D20826D

Q27676990-DDA384B1-A3E5-419A-9A87-DB2950CED173

P2860

Q27676990-3EB63739-321D-4711-8625-DD8CCD549B4F

Q27676990-43EBBA8B-5DDC-48ED-93B2-6C5B2EC93D39

Q27676990-4FB12E51-2D21-4E5D-902C-B317F10C5041

Q27676990-58D722C2-A0E6-4AE0-80BD-75828AA5D7C9

Q27676990-779E9A79-B9D9-492B-AEBF-C00F3D784C45

Q27676990-7FB24D6D-0F23-4A67-A268-49078E30AC1B

Q27676990-909B7BCA-B3CB-441D-ADCE-D37D9328B48A

Q27676990-9AACB820-BC3E-49BC-A6A3-DA83E31F0A23

Q27676990-BAF7F712-A392-4EF9-84CB-BD9621B89831

Q27676990-C802CDE9-AA86-48E6-A2EC-043945DBF4A9

P304

Q27676990-D2E8B270-DD22-4828-AB05-A7932B36F5CF

P31

Q27676990-968B8C7A-A4E0-40B5-8A59-2E2738008285

P356

Q27676990-E34DEA82-E6E8-4A08-B824-5E9C6802337E

P433

Q27676990-A106B211-25E6-4AAB-84EA-FEB50302CA8E

P478

Q27676990-FF25CEA1-7C55-4D15-BA05-BBD4CBC7255E

P577

Q27676990-AB7BE9A2-B39E-40D4-9737-25BE1CD396CC

P5875

Q27676990-CBE67DE7-3F46-4AA4-9B53-63A2A03804BE

P698

Q27676990-083F20AB-0BB2-4053-ACAE-BBC41691DBD0

P921

Q27676990-8F877F0C-2A10-4C75-A62E-11DD00E85EBF

Q27676990-A32A460A-01E6-4734-8252-B1A435ADDBC9

Q27676990-DD547B7A-206C-4A37-B1DC-5072095B1035

P932

Q27676990-46011CE2-69BF-42A4-926B-AB29703FA88A

P356

S1744309111051219

P1433

Acta Crystallographica Section F: Structural Biology Communications

P1476

Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939

@en

P2093

Aleem Fazal

http://www.w3.org/2001/XMLSchema#string

Atwood Cheung

http://www.w3.org/2001/XMLSchema#string

Christina A Kirby

http://www.w3.org/2001/XMLSchema#string

Michael D Shultz

http://www.w3.org/2001/XMLSchema#string

Travis Stams

http://www.w3.org/2001/XMLSchema#string

P2860

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Zinc binding catalytic domain of human tankyrase 1

PHENIX: a comprehensive Python-based system for macromolecular structure solution

PROCHECK: a program to check the stereochemical quality of protein structures

Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3

Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor

Phasercrystallographic software

Features and development of Coot

Poly(ADP-ribose): novel functions for an old molecule

P304

115-8

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1107/S1744309111051219

http://www.w3.org/2001/XMLSchema#string

P433

Pt 2

http://www.w3.org/2001/XMLSchema#string

P478

68

http://www.w3.org/2001/XMLSchema#string

P577

2012-02-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

221798978

http://www.w3.org/2001/XMLSchema#string

P698

22297980

http://www.w3.org/2001/XMLSchema#string

P921

condensed matter physics

structural biology

P932

3274384

http://www.w3.org/2001/XMLSchema#string