Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)
about
Manipulation of the host protein acetylation network by human immunodeficiency virus type 1The bromodomain: from epigenome reader to druggable targetCyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of BromodomainsDiscovery of Novel Small-Molecule Inhibitors of BRD4 Using Structure-Based Virtual ScreeningStructure-Guided Design of Potent Diazobenzene Inhibitors for the BET BromodomainsAcetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase InhibitorsDiscovery, Design, and Optimization of Isoxazole Azepine BET InhibitorsNaphthyridines as novel BET family bromodomain inhibitorsObserved bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain InhibitorsNMR Fragment Screening Hit Induces Plasticity of BRD7/9 BromodomainsTargeting bromodomains: epigenetic readers of lysine acetylationTargeting BET bromodomains for cancer treatmentDrug Discovery Targeting Bromodomain-Containing Protein 4.Privileged diazepine compounds and their emergence as bromodomain inhibitors.Chromatin proteins and modifications as drug targets.BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD.BET bromodomain inhibitors: a patent review.Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulationEpigenetic modulation of type-1 diabetes via a dual effect on pancreatic macrophages and β cells.BET bromodomain proteins are required for glioblastoma cell proliferation.BET bromodomain inhibition suppresses graft-versus-host disease after allogeneic bone marrow transplantation in mice.Brd4 bridges the transcriptional regulators, Aire and P-TEFb, to promote elongation of peripheral-tissue antigen transcripts in thymic stromal cellsMapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk.Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discoverySynergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinibInduction of USP17 by combining BET and HDAC inhibitors in breast cancer cellsBeyond receptors and signaling: epigenetic factors in the regulation of innate immunityPhenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.Bromodomains and their pharmacological inhibitors.Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical evidence.Inhibitors of emerging epigenetic targets for cancer therapy: a patent review (2010-2014).Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.Progress in the Development of non-BET Bromodomain Chemical Probes.Bromodomains in Protozoan Parasites: Evolution, Function, and Opportunities for Drug Development.Bromodomain and extra-terminal (BET) family proteins: New therapeutic targets in major diseases.Protein-protein interaction inhibitors: advances in anticancer drug design.The bromodomain protein BRD4 regulates splicing during heat shock.Bromodomains: are readers right for epigenetic therapy?
P2860
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P2860
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)
description
2012 nî lūn-bûn
@nan
2012 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@ast
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@en
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@nl
type
label
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@ast
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@en
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@nl
prefLabel
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@ast
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@en
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@nl
P2093
P3181
P1476
Identification of a novel seri ...... file of I-BET151 (GSK1210151A)
@en
P2093
Ann L Walker
Anne Bouillot
Chun-Wa Chung
David Lugo
David M Wilson
Edwige Nicodeme
Françoise Gellibert
Frédéric Donche
Gael Krysa
Inma Rioja
P304
P3181
P356
10.1016/J.BMCL.2012.02.041
P407
P577
2012-02-24T00:00:00Z