Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
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Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptorsTwo distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.Recruitment of the class II phosphoinositide 3-kinase C2beta to the epidermal growth factor receptor: role of Grb2Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiationPhosphoinositides: tiny lipids with giant impact on cell regulationCrystal structures of PI3K-C2α PX domain indicate conformational change associated with ligand bindingThe Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cellsOxidative stress impairs insulin but not platelet-derived growth factor signalling in 3T3-L1 adipocytesHepatocyte growth factor activates phosphoinositide 3-kinase C2 beta in renal brush-border plasma membranesPhosphoinositide 3-kinase C2β regulates RhoA and the actin cytoskeleton through an interaction with DblThe role of collybistin in gephyrin clustering at inhibitory synapses: facts and open questions.Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways.Endosomal Phosphatidylinositol 3-Phosphate Promotes Gephyrin Clustering and GABAergic Neurotransmission at Inhibitory Postsynapses.Overstimulation can create health problems due to increases in PI3K/Akt/GSK3 insensitivity and GSK3 activity.Insulin/IGF-1 signaling, including class II/III PI3Ks, β-arrestin and SGK-1, is required in C. elegans to maintain pharyngeal muscle performance during starvation.The class II phosphatidylinositol 3-phosphate kinase PIK3C2A promotes Shigella flexneri dissemination through formation of vacuole-like protrusions.Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori.Turning signals on and off: GLUT4 traffic in the insulin-signaling highway.Class II phosphoinositide 3-kinase defines a novel signaling pathway in cell migration.Inactivation of the Class II PI3K-C2β Potentiates Insulin Signaling and SensitivityPhosphoinositide regulation of neuroexocytosis: adding to the complexity.Emerging roles of phosphatidylinositol 3-monophosphate as a dynamic lipid second messenger.Phosphatidylinositol 3-phosphates-at the interface between cell signalling and membrane traffic.Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.Multiple roles for the p85α isoform in the regulation and function of PI3K signalling and receptor trafficking.Targeting PI3K in Cancer: Any Good News?Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.PI3K-C2α: One enzyme for two products coupling vesicle trafficking and signal transduction.Class II phosphoinositide 3-kinase C2alpha: what we learned so farInsulin induces phosphatidylinositol-3-phosphate formation through TC10 activation.PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signallingMyotubularin, a phosphatase deficient in myotubular myopathy, acts on phosphatidylinositol 3-kinase and phosphatidylinositol 3-phosphate pathway.Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.The alpha-isoform of class II phosphoinositide 3-kinase is more effectively activated by insulin receptors than IGF receptors, and activation requires receptor NPEY motifs.Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivoContraction inhibits insulin-stimulated insulin receptor substrate-1/2-associated phosphoinositide 3-kinase activity, but not protein kinase B activation or glucose uptake, in rat muscle.Requirement for class II phosphoinositide 3-kinase C2alpha in maintenance of glomerular structure and functionPresence and activation of nuclear phosphoinositide 3-kinase C2beta during compensatory liver growth.
P2860
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P2860
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@ast
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@en
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@nl
type
label
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@ast
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@en
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@nl
prefLabel
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@ast
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@en
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@nl
P2093
P3181
P356
P1476
Insulin activates the alpha isoform of class II phosphoinositide 3-kinase
@en
P2093
M D Waterfield
P R Shepherd
P304
P3181
P356
10.1074/JBC.274.21.14529
P407
P577
1999-05-21T00:00:00Z