Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism - Wikidata - awgldk - TriplyDB

Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism

Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism

http://www.wikidata.org/entity/Q34748262

about

Identification and characterization of DEDD2, a death effector domain-containing protein Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD The PEA-15 protein regulates autophagy via activation of JNK On the Quest of Cellular Functions of PEA-15 and the Therapeutic Opportunities Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function Vanishin is a novel ubiquitinylated death-effector domain protein that blocks ERK activation Hippocampal signaling cascades are modulated in voluntary and treadmill exercise rats PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15.PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin.A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation.Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.Cyclic AMP selectively uncouples mitogen-activated protein kinase cascades from activating signals Akt down-regulates ERK1/2 nuclear localization and angiotensin II-induced cell proliferation through PEA-15.PEA-15 modulates TNFalpha intracellular signaling in astrocytes.PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15).High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective.Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival.Residues 762-801 of PLD1 mediate the interaction with PED/PEA15.PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells.Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation.MicroRNA-128 governs neuronal excitability and motor behavior in mice PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.Calcium/calmodulin-dependent protein kinase II regulation of c-FLIP expression and phosphorylation in modulation of Fas-mediated signaling in malignant glioma cells.The PEA15 gene is overexpressed and related to insulin resistance in healthy first-degree relatives of patients with type 2 diabetes.Nucleocytoplasmic p27Kip1 Export Is Required for ERK1/2-Mediated Reactive Astroglial Proliferation Following Status Epilepticus.

P2860

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P2860

Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism

http://www.wikidata.org/entity/Q34748262

description

2000 nî lūn-bûn

@nan

2000 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

name

Death effector domain protein ...... adhesion-independent mechanism

@ast

Death effector domain protein ...... adhesion-independent mechanism

@en

Death effector domain protein ...... adhesion-independent mechanism

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type

label

Death effector domain protein ...... adhesion-independent mechanism

@ast

Death effector domain protein ...... adhesion-independent mechanism

@en

Death effector domain protein ...... adhesion-independent mechanism

@nl

prefLabel

Death effector domain protein ...... adhesion-independent mechanism

@ast

Death effector domain protein ...... adhesion-independent mechanism

@en

Death effector domain protein ...... adhesion-independent mechanism

@nl

P1433

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P1476

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P2860

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Q34748262-EC4AB438-16DE-4BF4-BF72-B305CAE91BBD

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P932

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P356

P1433

Molecular Biology of the Cell

P1476

Death effector domain protein ...... adhesion-independent mechanism

@en

P2093

E Formstecher

http://www.w3.org/2001/XMLSchema#string

J W Ramos

http://www.w3.org/2001/XMLSchema#string

M H Ginsberg

http://www.w3.org/2001/XMLSchema#string

M W Renshaw

http://www.w3.org/2001/XMLSchema#string

P E Hughes

http://www.w3.org/2001/XMLSchema#string

P2860

PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis

Structure of the human and murine R-ras genes, novel genes closely related to ras proto-oncogenes

A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain

FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis

MADD, a novel death domain protein that interacts with the type 1 tumor necrosis factor receptor and activates mitogen-activated protein kinase

PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus.

Inhibition of death receptor signals by cellular FLIP

The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human

Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method

P304

2863-2872

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P31

scholarly article

P356

10.1091/MBC.11.9.2863

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P433

9

http://www.w3.org/2001/XMLSchema#string

P478

11

http://www.w3.org/2001/XMLSchema#string

P50

Hervé Chneiweiss

Martin A Schwartz

P577

2000-09-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12340662

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P698

10982386

http://www.w3.org/2001/XMLSchema#string

P932

14961

http://www.w3.org/2001/XMLSchema#string