Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell
about
Endoplasmic reticulum stress and type 2 diabetesSynergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5Preferential release of newly synthesized insulin assessed by a multi-label reporter system using pancreatic β-cell line MIN6The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreasInsulin gene expression is regulated by DNA methylationRecessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis.Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells.Beta-cell specific deletion of Dicer1 leads to defective insulin secretion and diabetes mellitus.Polymorphism rs11085226 in the gene encoding polypyrimidine tract-binding protein 1 negatively affects glucose-stimulated insulin secretion.Functional mapping of disease susceptibility loci using cell biology.Glucotoxicity and beta-cell failure in type 2 diabetes mellitus.Chronic hyperglycemia downregulates GLP-1 receptor signaling in pancreatic β-cells via protein kinase AZip4 mediated zinc influx stimulates insulin secretion in pancreatic beta cells.Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes.Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.A small molecule differentiation inducer increases insulin production by pancreatic β cellsPlasticity of the beta cell insulin secretory competence: preparing the pancreatic beta cell for the next meal.RNA-binding protein HuD controls insulin translationCharacterization of Antibodies to Products of Proinsulin Processing Using Immunofluorescence Staining of Pancreas in Multiple Species.Birth weight modifies the association between central nervous system gene variation and adult body mass indexRole of furin in granular acidification in the endocrine pancreas: identification of the V-ATPase subunit Ac45 as a candidate substrate.Novel aspects of the molecular mechanisms controlling insulin secretion.Growth factor control of pancreatic islet regeneration and functionOxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen species.Endoplasmic reticulum stress and pancreatic β-cell death.Regulation of β-cell function by RNA-binding proteins.Advances in management of type 1 diabetes mellitus.Deregulation of pancreas-specific oxidoreductin ERO1β in the pathogenesis of diabetes mellitus.Hypomethylation of the promoter of the catalytic subunit of protein phosphatase 2A in response to hyperglycemia.The role of protein kinase D in neurotensin secretion mediated by protein kinase C-alpha/-delta and Rho/Rho kinase.Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.Peroxiredoxin 4 improves insulin biosynthesis and glucose-induced insulin secretion in insulin-secreting INS-1E cells.Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide.[Endoplasmic reticulum stress: from physiology to pathogenesis of type 2 diabetes].Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability.Glucocorticoid overexposure in neonatal life alters pancreatic beta-cell function in newborn foals.
P2860
Q26864238-63BB8B2C-DD22-4C4D-A8C7-60DF4280C430Q28117194-CEB380C9-8AD2-4037-8396-78DD4B46A266Q28484639-AFB153E3-EF73-4E8C-B067-A1865D333A19Q28505821-43F7C8C0-7BBE-4445-BA5D-89B303183CD5Q33501742-C750EF7C-F985-4921-B456-5FE5B27F8F32Q33733949-7DBBD0F0-DA01-4AB4-835F-1F4046A97458Q34074254-AF81E1AD-5AEA-47B3-8984-8DBBC6779FE9Q34079350-7B8CF156-3EBA-44CC-B9AF-34EB3E79114DQ34117281-CDF7337D-9295-4F18-A312-25163927B3D9Q34450307-6EAF04C2-F5BC-472B-82BB-9ED614B15D57Q34944028-F0FF3201-2F69-46B1-8BAD-9BE131283AE2Q35065639-D71FA01E-2580-415C-B2AD-0FDAA2EA09C5Q35163101-A762D7AA-04F8-427C-951E-42F21937C0DAQ35217220-94558F0E-4848-4DAC-81C4-C80ADCAC320CQ35498877-A282ACC8-310A-477E-BBBB-8092C0CDFDC4Q35585661-AECC1D95-A66F-46AF-97DF-B33CB871C0D6Q35651147-27ABAB48-C3E7-498D-A865-42B6F2D2F78EQ35794504-1A34AC80-62FC-4C84-8C4B-6101C9C77CA8Q35869792-4DBC8CE4-684C-4F3E-93A4-198A634F86FCQ35932759-296E2351-9B87-471C-9029-38D78BC4ACFAQ36730812-1CEAEEEB-88BF-4B44-B123-3DF9E20467F8Q36858525-C142BE3C-C9F7-4D54-B1C5-05FBD077E841Q37176911-EA75CD6C-2581-4E58-ABA5-CDD8FE8029B4Q37283982-3DBA7F10-6837-410A-9464-E2E0E1667013Q37401266-8BE5D996-FC85-4F0E-97AD-7C56E7A08E0EQ37860493-4E01A2E5-CF82-457A-966B-008E5112C554Q38170369-D683C6F3-F2E7-4543-B05F-7B58B2A91C7AQ38260399-B7867E6A-C74D-4BE8-9957-600E2B7795CBQ38855484-28DE3A42-C899-4A4D-A674-324B2A3F8342Q38944888-F84CF3D8-EF62-4064-825B-4986A9E45A48Q40559835-464E59CB-30DD-4D63-A3CA-2C360AA03DA2Q40663050-6AD1214A-BEEA-4F5D-871B-BC996A8264A9Q42915513-AA874A2A-06C3-47A9-94E0-73870CD3DFDCQ43083300-66682544-4CE0-4827-95C7-268425079F5EQ43571532-B846CB49-1A69-4566-BEB6-1EF3147A3B66Q44016473-B61AC47F-D502-42A3-942A-A465BE8A5BFFQ44826419-0563CD59-B10C-4F16-8034-B2FBE5B62C37Q47848107-D1001718-5731-4C80-AFA4-9C0E44EAE27DQ49917575-97292EB2-8D54-436E-895C-801179444894Q50778474-91057DB8-4611-4806-A2FC-248479D61E4E
P2860
Translational regulation of proinsulin biosynthesis and proinsulin conversion in the pancreatic beta-cell
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Translational regulation of pr ...... on in the pancreatic beta-cell
@ast
Translational regulation of pr ...... on in the pancreatic beta-cell
@en
Translational regulation of pr ...... on in the pancreatic beta-cell
@nl
type
label
Translational regulation of pr ...... on in the pancreatic beta-cell
@ast
Translational regulation of pr ...... on in the pancreatic beta-cell
@en
Translational regulation of pr ...... on in the pancreatic beta-cell
@nl
prefLabel
Translational regulation of pr ...... on in the pancreatic beta-cell
@ast
Translational regulation of pr ...... on in the pancreatic beta-cell
@en
Translational regulation of pr ...... on in the pancreatic beta-cell
@nl
P356
P1476
Translational regulation of pr ...... on in the pancreatic beta-cell
@en
P2093
J C Hutton
K A Goodge
P304
P356
10.1006/SCDB.2000.0172
P407
P577
2000-08-01T00:00:00Z