Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent. - Wikidata - awgldk - TriplyDB

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

http://www.wikidata.org/entity/Q36429538

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Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene A Review: Molecular Aberrations within Hippo Signaling in Bone and Soft-Tissue Sarcomas Meet the neighbors: Mapping local protein interactomes by proximity-dependent labeling with BioID Junction region of EWS-FLI1 fusion protein has a dominant negative effect in Ewing's sarcoma in vitro.Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro.Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.Novel peptide binds EWS-FLI1 and reduces the oncogenic potential in Ewing tumors.Assemblages: functional units formed by cellular phase separation Targeted Therapy of Ewing's Sarcoma.Protein tyrosine phosphatases as potential therapeutic targets.Oncogenic fusion protein EWS-FLI1 is a network hub that regulates alternative splicing.Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma.A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesis Fas/Fas ligand regulation mediates cell death in human Ewing's sarcoma cells treated with melatonin EWS-FLI-1-targeted cytotoxic T-cell killing of multiple tumor types belonging to the Ewing sarcoma family of tumors YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.The biology of ewing sarcoma Adult human sarcomas. I. Basic science.Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.PTPL1: a large phosphatase with a split personality.A molecular function map of Ewing's sarcoma.EWS Knockdown and Taxifolin Treatment Induced Differentiation and Removed DNA Methylation from p53 Promoter to Promote Expression of Puma and Noxa for Apoptosis in Ewing's Sarcoma Ewing's sarcoma: overcoming the therapeutic plateau.Adult primary pulmonary primitive neuroectodermal tumor: molecular features and translational opportunities.Blocking the road, stopping the engine or killing the driver? Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy.FLI1 is a novel ETS transcription factor involved in gene fusions in prostate cancer.EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.Suppression of FOXO1 is responsible for a growth regulatory repressive transcriptional sub-signature of EWS-FLI1 in Ewing sarcoma.Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.Molecular subtyping of primary prostate cancer reveals specific and shared target genes of different ETS rearrangements CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor₁₆₅ in Ewing sarcoma cells.Potential molecular targets for Ewing's sarcoma therapy.Eureka! Ets a target for fibrosis![Functional genomics of Ewing sarcoma].MYB deregulation from a EWSR1-MYB fusion at leukemic evolution of a JAK2 (V617F) positive primary myelofibrosis.Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts.Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

http://www.wikidata.org/entity/Q36429538

description

2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

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type

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

@ast

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

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14796694.1.4.521

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Future Oncology

P1476

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

@en

P2093

Aykut Uren

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Jeffrey A Toretsky

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P2860

Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells

EWS-FLI1 fusion transcript structure is an independent determinant of prognosis in Ewing's sarcoma.

The splicing factor U1C represses EWS/FLI-mediated transactivation

COL11A2 collagen gene transcription is differentially regulated by EWS/ERG sarcoma fusion protein and wild-type ERG

Common musculoskeletal tumors of childhood and adolescence.

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks.

EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin.

PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins

The dual-function CD150 receptor subfamily: the viral attraction.

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521-528

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scholarly article

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10.2217/14796694.1.4.521

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