Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR - Wikidata - awgldk - TriplyDB

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

http://www.wikidata.org/entity/Q28212465

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Endotoxin leads to rapid subcellular re-localization of hepatic RXRalpha: A novel mechanism for reduced hepatic gene expression in inflammation The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions The transcriptional regulation of the human CYP2C genes The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor Activation of xenobiotic receptors: driving into the nucleus.Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivo Sesamin: A Naturally Occurring Lignan Inhibits CYP3A4 by Antagonizing the Pregnane X Receptor Activation.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation.Role of CAR and PXR in xenobiotic sensing and metabolism.Expression of the PXR gene in various types of cancer and drug resistance Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.Shear stress activation of nuclear receptor PXR in endothelial detoxification.Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.Nuclear receptors: the controlling force in drug metabolism of the liver?Nonviral gene transfer as a tool for studying transcription regulation of xenobiotic metabolizing enzymes.Role of xenobiotic metabolism in cancer: involvement of transcriptional and miRNA regulation of P450s.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.Mechanisms of xenobiotic receptor activation: Direct vs. indirect.A SUMO-acetyl switch in PXR biology.Analysis of flavonoids regulating the expression of UGT1A1 via xenobiotic receptors in intestinal epithelial cells.Regulation of P-glycoprotein by orphan nuclear receptors in human brain microvessel endothelial cells.Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1.Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization.Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.A novel approach to investigate the subcellular distribution of nuclear receptors in vivo.Transcription coactivator PRIP, the peroxisome proliferator-activated receptor (PPAR)-interacting protein, is redundant for the function of nuclear receptors PParalpha and CAR, the constitutive androstane receptor, in mouse liver.PXR: More Than Just a Master Xenobiotic Receptor.

P2860

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P2860

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

http://www.wikidata.org/entity/Q28212465

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

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Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

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Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

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type

label

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

@ast

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

@en

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

@nl

prefLabel

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

@ast

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

@en

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

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Molecular Pharmacology

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Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

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Kaname Kawajiri

http://www.w3.org/2001/XMLSchema#string

Katsuyoshi Kawana

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Ken Takeda

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Osamu Gotoh

http://www.w3.org/2001/XMLSchema#string

Togo Ikuta

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Yasuhito Kobayashi

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524-31

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scholarly article

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10.1124/MOL.63.3.524

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3

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63

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2003-03-01T00:00:00Z

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12606758

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