Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
about
The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammalsBiology of PXR: role in drug-hormone interactionsRole of pregnane X receptor in chemotherapeutic treatmentChaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperonesPregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator InteractionsThe roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse liversPhenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXROverexpression of the Rho-guanine nucleotide exchange factor ECT2 inhibits nuclear translocation of nuclear receptor CAR in the mouse liverHuman pregnane X receptor is expressed in breast carcinomas, potential heterodimers formation between hPXR and RXR-alphaSulfotransferase genes: regulation by nuclear receptors in response to xeno/endo-biotics.Activation of xenobiotic receptors: driving into the nucleus.Evaluation of the HC-04 cell line as an in vitro model for mechanistic assessment of changes in hepatic cytochrome P450 3A during adenovirus infection.The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver.A mechanistic insight into 3,4-methylenedioxymethamphetamine ("ecstasy")-mediated hepatotoxicity.Overcoming drug resistance by regulating nuclear receptors.Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).Casein Kinase 2 (CK2)-mediated Phosphorylation of Hsp90β as a Novel Mechanism of Rifampin-induced MDR1 ExpressionNuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.Serine 350 of human pregnane X receptor is crucial for its heterodimerization with retinoid X receptor alpha and transactivation of target genes in vitro and in vivoCAR and PXR: the xenobiotic-sensing receptors.Transcriptional regulation of the human pregnane-X receptor.Synthetic drugs and natural products as modulators of constitutive androstane receptor (CAR) and pregnane X receptor (PXR).Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liverPXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity.Role of CAR and PXR in xenobiotic sensing and metabolism.A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.Minireview: the intersection of steroid receptors with molecular chaperones: observations and questionsInduction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations.Identification of Ginkgo biloba as a novel activator of pregnane X receptor.Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.Nuclear receptors as therapeutic targets in cholestatic liver diseases.Phosphorylation and protein-protein interactions in PXR-mediated CYP3A repression.Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents.A systematic analysis of predicted phosphorylation sites within the human pregnane X receptor protein.The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism.Nuclear receptors: the controlling force in drug metabolism of the liver?Long-term virus-induced alterations of CYP3A-mediated drug metabolism: a look at the virology, immunology and molecular biology of a multi-faceted problem.Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells.Nuclear receptor PXR, transcriptional circuits and metabolic relevance.Methods for the quantitative evaluation and prediction of CYP enzyme induction using human in vitro systems.
P2860
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P2860
Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Cytoplasmic localization of pr ...... translocation in mouse liver.
@en
type
label
Cytoplasmic localization of pr ...... translocation in mouse liver.
@en
prefLabel
Cytoplasmic localization of pr ...... translocation in mouse liver.
@en
P2093
P2860
P356
P1476
Cytoplasmic localization of pr ...... translocation in mouse liver.
@en
P2093
E James Squires
Masahiko Negishi
Tatsuya Sueyoshi
P2860
P304
49307-49314
P356
10.1074/JBC.M407281200
P407
P577
2004-09-02T00:00:00Z