"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists
about
Adenosine receptors as therapeutic targetsStructure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists.Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors.Multivalent dendrimeric and monomeric adenosine agonists attenuate cell death in HL-1 mouse cardiomyocytes expressing the A(3) receptorNucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists.Discovery of New Human A(2A) Adenosine Receptor Agonists: Design, Synthesis, and Binding Mode of Truncated 2-Hexynyl-4'-thioadenosine.Molecular probes for the A2A adenosine receptor based on a pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine scaffoldStructure-activity relationships of truncated C2- or C8-substituted adenosine derivatives as dual acting A₂A and A₃ adenosine receptor ligands.Reversine suppresses oral squamous cell carcinoma via cell cycle arrest and concomitantly apoptosis and autophagyReversine Induced Multinucleated Cells, Cell Apoptosis and Autophagy in Human Non-Small Cell Lung Cancer Cells.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates.Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.2-triazole-substituted adenosines: a new class of selective A3 adenosine receptor agonists, partial agonists, and antagonists.Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors.H2O2 stimulates cystic fibrosis transmembrane conductance regulator through an autocrine prostaglandin pathway, using multidrug-resistant protein-4Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine.Adenosine A(2A) receptor dynamics studied with the novel fluorescent agonist Alexa488-APEC.Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.Reversine induces cell cycle arrest, polyploidy, and apoptosis in human breast cancer cells.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.The 2,6-disubstituted purine reversine induces growth arrest and polyploidy in human cancer cells.Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle.3D-e-Chem: Structural Cheminformatics Workflows for Computer-Aided Drug Discovery.Reversine, a substituted purine, exerts an inhibitive effect on human renal carcinoma cells via induction of cell apoptosis and polyploidy.Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells
P2860
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P2860
"Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@ast
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@en
type
label
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@ast
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@en
prefLabel
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@ast
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@en
P2093
P2860
P50
P356
P1476
"Reversine" and its 2-substitu ...... adenosine receptor antagonists
@en
P2093
Asher Shainberg
Athena M Klutz
Craig J Thomas
Jian-Kang Jiang
Melissa Perreira
P2860
P304
P356
10.1021/JM050221L
P407
P577
2005-07-01T00:00:00Z