Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function
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The PEA-15 protein regulates autophagy via activation of JNKProtein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic actionOmi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15Overexpression of the ped/pea-15 gene causes diabetes by impairing glucose-stimulated insulin secretion in addition to insulin actionPhosphorylation-regulated degradation of the tumor-suppressor form of PED by chaperone-mediated autophagy in lung cancer cells.PED/PEA-15 inhibits hydrogen peroxide-induced apoptosis in Ins-1E pancreatic beta-cells via PLD-1tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosisCharacterization of a MAPK scaffolding protein logic gate in gonadotropes.In vivo and in vitro assessment of pathways involved in contrast media-induced renal cells apoptosis.PED is overexpressed and mediates TRAIL resistance in human non-small cell lung cancer.An astrocyte-specific proteomic approach to inflammatory responses in experimental rat glaucomaAbsence of caspase 8 and high expression of PED protect primitive neural cells from cell death.Peroxisome proliferator-activated receptor-γ activation enhances insulin-stimulated glucose disposal by reducing ped/pea-15 gene expression in skeletal muscle cells: evidence for involvement of activator protein-1Impact of human cytomegalovirus latent infection on myeloid progenitor cell gene expression.Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade gliomaThe potential role of increasing the release of mouse β- defensin-14 in the treatment of osteomyelitis in mice: a primary study.Targetting PED/PEA-15 for diabetes treatment.Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15.Raised expression of the antiapoptotic protein ped/pea-15 increases susceptibility to chemically induced skin tumor development.Comparative analysis of phosphoprotein-enriched myocyte proteomes reveals widespread alterations during differentiation.PED/PEA-15 interacts with the 67 kD laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis.PED/PEA-15 controls fibroblast motility and wound closure by ERK1/2-dependent mechanisms.Molecular cloning and characterization of the human PED/PEA-15 gene promoter reveal antagonistic regulation by hepatocyte nuclear factor 4alpha and chicken ovalbumin upstream promoter transcription factor II.Phosphoprotein enriched in diabetes (PED/PEA15) promotes migration in hepatocellular carcinoma and confers resistance to sorafenib.Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells.Targeting of PED/PEA-15 molecular interaction with phospholipase D1 enhances insulin sensitivity in skeletal muscle cells.Phorbol esters induce intracellular accumulation of the anti-apoptotic protein PED/PEA-15 by preventing ubiquitinylation and proteasomal degradation.
P2860
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P2860
Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function
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2002 nî lūn-bûn
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2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@ast
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@en
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@nl
type
label
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@ast
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@en
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@nl
prefLabel
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@ast
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@en
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@nl
P2093
P2860
P50
P356
P1476
Multiple members of the mitoge ...... PEA-15 anti-apoptotic function
@en
P2093
Alessandra Trencia
Angela Cassese
Anna Perfetti
Claudia Miele
Francesco Beguinot
Giovanni Vigliotta
Stefania Santopietro
Umberto Goglia
P2860
P304
11013-11018
P356
10.1074/JBC.M110934200
P407
P577
2002-01-14T00:00:00Z