Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). - Wikidata - awgldk - TriplyDB

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

http://www.wikidata.org/entity/Q34922043

about

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma AID/APOBEC deaminases and cancer RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome AID targeting: old mysteries and new challenges AID and Apobec3G haphazard deamination and mutational diversity Accurate molecular classification of cancer using simple rules Role of the translocation partner in protection against AID-dependent chromosomal translocations Attracting AID to targets of somatic hypermutation.Generation and repair of AID-initiated DNA lesions in B lymphocytes.Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes Origin of chromosomal translocations in lymphoid cancer.Genome-wide somatic hypermutation.A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression Msh6 protects mature B cells from lymphoma by preserving genomic stability.AID-targeting and hypermutation of non-immunoglobulin genes does not correlate with proximity to immunoglobulin genes in germinal center B cells.Targeting of somatic hypermutation.Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation Complex regulation and function of activation-induced cytidine deaminase.Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice.Comparison of identical and functional Igh alleles reveals a nonessential role for Eμ in somatic hypermutation and class-switch recombination Translocation capture sequencing: a method for high throughput mapping of chromosomal rearrangements.DNA deamination in immunity.AID to overcome the limitations of genomic information.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.A role for AID in chromosome translocations between c-myc and the IgH variable region.The very 5' end and the constant region of Ig genes are spared from somatic mutation because AID does not access these regions Mutations within the 5' region of FAS/CD95 gene in nodal diffuse large B-cell lymphoma.Identification of a secondary promoter within the human B cell receptor component gene hCD79b Analysis of intergenic transcription and histone modification across the human immunoglobulin heavy-chain locus AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching.Activation-induced cytidine deaminase in antibody diversification and chromosome translocation.The role of activation-induced deaminase in antibody diversification and genomic instability.Immunomodulation and lymphoma in humans.Epigenetic function of activation-induced cytidine deaminase and its link to lymphomagenesis Differential regulation of mTOR signaling determines sensitivity to AKT inhibition in diffuse large B cell lymphoma.CD79B limits response of diffuse large B cell lymphoma to ibrutinib.Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation.Activation-induced cytidine deaminase targets SUV4-20-mediated histone H4K20 trimethylation to class-switch recombination sites.

P2860

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P2860

Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).

http://www.wikidata.org/entity/Q34922043

description

2003 nî lūn-bûn

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2003 թուականի Մարտին հրատարակուած գիտական յօդուած

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2003 թվականի մարտին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

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Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

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Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

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type

label

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@ast

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@en

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@nl

prefLabel

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@ast

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@en

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@nl

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PNAS.0735266100

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Somatic hypermutation of the B ...... 79b) and mb1 (Igalpha, CD79a).

@en

P2093

Cindy M Kanegai

http://www.w3.org/2001/XMLSchema#string

Jeanette R Doerr

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Melinda S Gordon

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Randolph Wall

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P2860

Isolation and chromosomal mapping of the human immunoglobulin-associated B29 gene (IGB)

Somatic hypermutation of the AID transgene in B and non-B cells

Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma

The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction

Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail

Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

Bob1 (OCA-B/OBF-1) differential transactivation of the B cell-specific B29 (Ig beta) and mb-1 (Ig alpha) promoters

AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas

P304

4126-4131

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10.1073/PNAS.0735266100

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7

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100

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10842786

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12651942

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153059

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