Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty - Wikidata - awgldk - TriplyDB

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

http://www.wikidata.org/entity/Q28276922

about

A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1 Phosphorylation mechanism and structure of serine-arginine protein kinases Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1 Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation Structural basis for nuclear import of splicing factors by human Transportin 3 Unphosphorylated SR-like protein Npl3 stimulates RNA polymerase II elongation.Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1 Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function Programming with models: modularity and abstraction provide powerful capabilities for systems biology.Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer.Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa.Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1 Differential effect of CLK SR Kinases on HIV-1 gene expression: potential novel targets for therapy.Structural basis for regulation of RNA-binding proteins by phosphorylation.Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1 Phosphoproteomics reveals extensive in vivo phosphorylation of Arabidopsis proteins involved in RNA metabolism.Prediction of cyclin-dependent kinase phosphorylation substrates.Processive phosphorylation: mechanism and biological importance The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus.Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation.Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases.Redirecting SR Protein Nuclear Trafficking through an Allosteric Platform.Protein kinase a-dependent phosphorylation of serine 119 in the proto-oncogenic serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein Nuclear protein kinase CLK1 uses a non-traditional docking mechanism to select physiological substrates.Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1.Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1.Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones.Regulation of alternative VEGF-A mRNA splicing is a therapeutic target for analgesia.Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1.Recruiting a silent partner for activation of the protein kinase SRPK1 Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate.Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein-protein interactions.Targeting Splicing in Prostate Cancer.

P2860

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P2860

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

http://www.wikidata.org/entity/Q28276922

description

2005 nî lūn-bûn

@nan

2005 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@ast

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@en

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

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type

label

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@ast

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@en

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@nl

prefLabel

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@ast

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@en

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@nl

P1433

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P2860

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P921

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P356

P1433

Journal of Biological Chemistry

P1476

Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty

@en

P2093

Adolfo Velazquez-Dones

http://www.w3.org/2001/XMLSchema#string

Chen-Ting Ma

http://www.w3.org/2001/XMLSchema#string

Gourisankar Ghosh

http://www.w3.org/2001/XMLSchema#string

Jonathan C Hagopian

http://www.w3.org/2001/XMLSchema#string

Joseph A Adams

http://www.w3.org/2001/XMLSchema#string

Xiang-Dong Fu

http://www.w3.org/2001/XMLSchema#string

Xiang-Yang Zhong

http://www.w3.org/2001/XMLSchema#string

P2860

The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)

Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins

The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing

SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2.

Transportin-SR2 mediates nuclear import of phosphorylated SR proteins

A novel role for shuttling SR proteins in mRNA translation

Processive phosphorylation of alternative splicing factor/splicing factor 2

Regulation and substrate specificity of the SR protein kinase Clk/Sty

P304

41761-41768

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scholarly article

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10.1074/JBC.M504156200

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50

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P478

280

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P577

2005-10-13T00:00:00Z

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16223727

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P921

phosphorylation