Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
about
MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groupsFANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity.Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3.The Fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factorsDisruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin CFanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complexHow the fanconi anemia pathway guards the genomeEvidence for at least eight Fanconi anemia genesFanconi anaemiaFanconi anemia genes are highly expressed in primitive CD34+ hematopoietic cellsUpdate of the human and mouse Fanconi anemia genesGenetics of the ovarian reserveOxidative stress, bone marrow failure, and genome instability in hematopoietic stem cellsModeling the study of DNA damage responses in miceLearning from a paradox: recent insights into Fanconi anaemia through studying mouse modelsEpithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout miceMouse models of Fanconi anemiaFancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in miceLoss of GGN leads to pre-implantation embryonic lethality and compromised male meiotic DNA double strand break repair in the mouseThe Fanconi anemia pathway and ubiquitinCytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cellsFunctional activity of the fanconi anemia protein FAA requires FAC binding and nuclear localization.Fanconi anemia proteins and their interacting partners: a molecular puzzleA concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage.Hypersensitivity of primordial germ cells to compromised replication-associated DNA repair involves ATM-p53-p21 signalingDisruption of murine Mus81 increases genomic instability and DNA damage sensitivity but does not promote tumorigenesis.Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.Human FANCC is hypomorphic in murine Fancc-deficient cellsDNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes.FANCB is essential in the male germline and regulates H3K9 methylation on the sex chromosomes during meiosis.The phenotype of FancB-mutant mouse embryonic stem cells.Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion.Enhanced TNF-alpha-induced apoptosis in Fanconi anemia type C-deficient cells is dependent on apoptosis signal-regulating kinase 1.Scientific and clinical opportunities for modeling blood disorders with embryonic stem cellsPrimary Ovarian Insufficiency Induced by Fanconi Anemia E Mutation in a Mouse Model.Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.Fancb deficiency impairs hematopoietic stem cell function.The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
P2860
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P2860
Germ cell defects and hematopoietic hypersensitivity to gamma-interferon in mice with a targeted disruption of the Fanconi anemia C gene
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@ast
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@en
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@nl
type
label
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@ast
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@en
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@nl
prefLabel
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@ast
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@en
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@nl
P2093
P3181
P1433
P1476
Germ cell defects and hematopo ...... n of the Fanconi anemia C gene
@en
P2093
C Reifsteck
M A Whitney
M C Heinrich
M K Axthelm
P3181
P407
P577
1996-07-01T00:00:00Z