The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
about
Localisation and mislocalisation of the interferon-inducible immunity-related GTPase, Irgm1 (LRG-47) in mouse cellsCoordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuoleThe immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell deathAutophagy and pattern recognition receptors in innate immunityAutophagy in immunity against mycobacterium tuberculosis: a model system to dissect immunological roles of autophagyInterferon-inducible immunity-related GTPase Irgm1 regulates IFN gamma-dependent host defense, lymphocyte survival and autophagyStriking the Right Balance Determines TB or Not TBThe polymorphic pseudokinase ROP5 controls virulence in Toxoplasma gondii by regulating the active kinase ROP18Autophagy, Immunity, and Microbial AdaptationsHematopoietic Stem Cell Regulation by Type I and II Interferons in the Pathogenesis of Acquired Aplastic AnemiaStress and Non-Stress Roles of Inflammatory Signals during HSC Emergence and MaintenanceRegulatory interactions between IRG resistance GTPases in the cellular response to Toxoplasma gondiiAtaxin1L is a regulator of HSC function highlighting the utility of cross-tissue comparisons for gene discoveryRegulation of macrophage motility by Irgm1The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cellsCD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells.Transient activation of hematopoietic stem and progenitor cells by IFNγ during acute bacterial infection.The mouse resistance protein Irgm1 (LRG-47): a regulator or an effector of pathogen defense?Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cellsCD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathwayImprinted genes that regulate early mammalian growth are coexpressed in somatic stem cells.Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection.Dnmt3a is essential for hematopoietic stem cell differentiation.Fluorescent function-spacer-lipid construct labelling allows for real-time in vivo imaging of cell migration and behaviour in zebrafish (Danio rerio).Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells.Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Autophagy in immunity and cell-autonomous defense against intracellular microbesAutophagy and HIVAtypical protein kinase C (aPKCzeta and aPKClambda) is dispensable for mammalian hematopoietic stem cell activity and blood formationIrgm1 protects hematopoietic stem cells by negative regulation of IFN signalingInfection-induced myelopoiesis during intracellular bacterial infection is critically dependent upon IFN-γ signaling.Pathogenesis of Crohn's diseaseLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection.The immunity-related GTPases in mammals: a fast-evolving cell-autonomous resistance system against intracellular pathogens.Signal transduction pathways, intrinsic regulators, and the control of cell fate choice.Balance of Irgm protein activities determines IFN-gamma-induced host defenseIrgm1-deficient mice exhibit Paneth cell abnormalities and increased susceptibility to acute intestinal inflammation.Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis.Multiple regulatory and effector roles of autophagy in immunity.Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons.
P2860
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P2860
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@ast
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@en
type
label
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@ast
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@en
prefLabel
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@ast
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@en
P2093
P2860
P1433
P1476
The p47 GTPase Lrg-47 (Irgm1) ...... ietic stem cell proliferation.
@en
P2093
David C Weksberg
Gregory A Taylor
P2860
P356
10.1016/J.STEM.2007.10.007
P407
P577
2008-01-01T00:00:00Z