Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator - Wikidata - awgldk - TriplyDB

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

http://www.wikidata.org/entity/Q28344284

about

Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros The Ikaros family of zinc-finger proteins Congenital pancytopenia and absence of B lymphocytes in a neonate with a mutation in the Ikaros gene Unconventional potentiation of gene expression by Ikaros Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros The nuclear oncoprotein TLX1/HOX11 associates with pericentromeric satellite 2 DNA in leukemic T-cells Repression of myelin proteolipid protein gene expression is mediated through both general and cell type-specific negative regulatory elements in nonexpressing cells Ikaros and RAG-2-mediated antisense transcription are responsible for lymphocyte-specific inactivation of NWC promoter.Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice Protein phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell leukemia.Epigenetic regulation of T cell fate and function.Mast cell IL-4 expression is regulated by Ikaros and influences encephalitogenic Th1 responses in EAE Haematopoietic cell-fate decisions, chromatin regulation and ikaros.Critical function of Ikaros in controlling Aiolos gene expression.Hematopoietic cytokines, transcription factors and lineage commitment.Predominant interaction of both Ikaros and Helios with the NuRD complex in immature thymocytes.Human hematopoietic lineage commitment.Regulator of myeloid differentiation and function: The secret life of Ikaros.Ikaros isoforms: The saga continues.The establishment and maintenance of lymphocyte identity through gene silencing.Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells.Monoallelic gene expression: a repertoire of recurrent themes.Regulation of gene expression dynamics during developmental transitions by the Ikaros transcription factor.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.Transcriptional networks in developing and mature B cells.Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.Ikaros promotes early-born neuronal fates in the cerebral cortex.Ikaros controls isotype selection during immunoglobulin class switch recombination.Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.Something silent this way forms: the functional organization of the repressive nuclear compartment.Clinical consequences of defects in B-cell development.Ikaros in immune receptor signaling, lymphocyte differentiation, and function.Ikaros, CK2 kinase, and the road to leukemia.Ikaros and tumor suppression in acute lymphoblastic leukemia Direct protein interactions are responsible for Ikaros-GATA and Ikaros-Cdk9 cooperativeness in hematopoietic cells A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains.Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros.Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation.The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros.

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P2860

Down-regulation of TDT transcription in CD4(+)CD8(+) thymocytes by Ikaros proteins in direct competition with an Ets activator

http://www.wikidata.org/entity/Q28344284

description

2001 nî lūn-bûn

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2001 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2001 թվականի հուլիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Down-regulation of TDT transcr ...... petition with an Ets activator

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Genes & Development

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Down-regulation of TDT transcr ...... petition with an Ets activator

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A S Weinmann

http://www.w3.org/2001/XMLSchema#string

B S Cobb

http://www.w3.org/2001/XMLSchema#string

I P Garraway

http://www.w3.org/2001/XMLSchema#string

K Hahm

http://www.w3.org/2001/XMLSchema#string

L A Trinh

http://www.w3.org/2001/XMLSchema#string

R Ferrini

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S T Smale

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P2860

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development

Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin

The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene

Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

The Ikaros gene encodes a family of functionally diverse zinc finger DNA-binding proteins

The Ikaros gene is required for the development of all lymphoid lineages

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

The "initiator" as a transcription control element

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1817-1832

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scholarly article

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4746936

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10.1101/GAD.905601

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14

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15

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Matthias Merkenschlager

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2001-07-01T00:00:00Z

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11881850

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11459831

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312741

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