Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine - Wikidata - awgldk - TriplyDB

Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

http://www.wikidata.org/entity/Q28366801

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Ratcheting up protein translocation with anthrax toxin Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine.Acyldepsipeptide antibiotics induce the formation of a structured axial channel in ClpP: A model for the ClpX/ClpA-bound state of ClpP.The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease Structural Dynamics of the MecA-ClpC Complex: A TYPE II AAA+ PROTEIN UNFOLDING MACHINE Cooperation of Hsp70 and Hsp100 chaperone machines in protein disaggregation Torsins: not your typical AAA+ ATPases Conformational switching of the 26S proteasome enables substrate degradation AAA+ proteins: have engine, will work Stepwise unfolding of a β barrel protein by the AAA+ ClpXP protease.Role of a conserved pore residue in the formation of a prehydrolytic high substrate affinity state in the AAA+ chaperone ClpA Cleavage site selection within a folded substrate by the ATP-dependent lon protease.Partitioning between unfolding and release of native domains during ClpXP degradation determines substrate selectivity and partial processing.Binding of the ClpA unfoldase opens the axial gate of ClpP peptidase ClpAP and ClpXP degrade proteins with tags located in the interior of the primary sequence.The N-end rule pathway and regulation by proteolysis ClpXP, an ATP-powered unfolding and protein-degradation machine Remodeling of a delivery complex allows ClpS-mediated degradation of N-degron substrates.Chloroplastic Hsp100 chaperones ClpC2 and ClpD interact in vitro with a transit peptide only when it is located at the N-terminus of a protein.Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine.Nucleotide-dependent substrate recognition by the AAA+ HslUV protease.The mechanism of Torsin ATPase activation.A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases.Dependence of proteasome processing rate on substrate unfolding Assaying the kinetics of protein denaturation catalyzed by AAA+ unfolding machines and proteases TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching Structure and function of the middle domain of ClpB from Escherichia coli.Coarse-Grained Simulations of Topology-Dependent Mechanisms of Protein Unfolding and Translocation Mediated by ClpY ATPase Nanomachines Sculpting the proteome with AAA(+) proteases and disassembly machines.Processive ATP-driven substrate disassembly by the N-ethylmaleimide-sensitive factor (NSF) molecular machine.Deciphering the Roles of Multicomponent Recognition Signals by the AAA+ Unfoldase ClpX.Slicing a protease: structural features of the ATP-dependent Lon proteases gleaned from investigations of isolated domains.Distinct peptide signals in the UmuD and UmuD' subunits of UmuD/D' mediate tethering and substrate processing by the ClpXP protease.Lethal factor unfolding is the most force-dependent step of anthrax toxin translocation.SspB delivery of substrates for ClpXP proteolysis probed by the design of improved degradation tags Towards a unifying mechanism for ClpB/Hsp104-mediated protein disaggregation and prion propagation.The unfolding story of anthrax toxin translocation.Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines.Mini review: ATP-dependent proteases in bacteria.Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity.

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Effects of protein stability and structure on substrate processing by the ClpXP unfolding and degradation machine

http://www.wikidata.org/entity/Q28366801

description

2001 nî lūn-bûn

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2001 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2001 թվականի հունիսին հրատարակված գիտական հոդված

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2001年の論文

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2001年论文

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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Effects of protein stability a ...... olding and degradation machine

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P1433

The EMBO Journal

P1476

Effects of protein stability a ...... olding and degradation machine

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P2093

R E Burton

http://www.w3.org/2001/XMLSchema#string

R T Sauer

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S M Siddiqui

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T A Baker

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Y I Kim

http://www.w3.org/2001/XMLSchema#string

P2860

The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system

Crystal structure, folding, and operator binding of the hyperstable Arc repressor mutant PL8

The structure of ClpP at 2.3 A resolution suggests a model for ATP-dependent proteolysis

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone

Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA

Global unfolding of a substrate protein by the Hsp100 chaperone ClpA.

Molecular determinants of complex formation between Clp/Hsp100 ATPases and the ClpP peptidase.

An essential protease involved in bacterial cell-cycle control.

The SsrA-SmpB system for protein tagging, directed degradation and ribosome rescue.

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

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3092-100

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10.1093/EMBOJ/20.12.3092

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12

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P478

20

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2001-06-15T00:00:00Z

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11932483

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P698

11406586

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P921

protein structure

P932

150209

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