Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase
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Crystal structures of a pantothenate synthetase fromM. tuberculosisand its complexes with substrates and a reaction intermediateInhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction IntermediateThe 1.6 Å Crystal Structure of Mycobacterium smegmatis MshC: The Penultimate Enzyme in the Mycothiol Biosynthetic Pathway †A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial ChemistryOptimization of the Interligand Overhauser Effect for Fragment Linking: Application to Inhibitor Discovery against Mycobacterium tuberculosis Pantothenate SynthetaseIntegrated biophysical approach to fragment screening and validation for fragment-based lead discoveryA high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosisPurification, crystallization and data collection of methicillin-resistant Staphylococcus aureus Sar2676, a pantothenate synthetaseInhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.Multipathway Integrated Adjustment Mechanism of Glycyrrhiza Triterpenes Curing Gastric Ulcer in Rats.Acetylation of acetyl-CoA synthetase from Mycobacterium tuberculosis leads to specific inactivation of the adenylation reactionRational design of a Corynebacterium glutamicum pantothenate production strain and its characterization by metabolic flux analysis and genome-wide transcriptional profiling.Characterization and kinetics of phosphopantothenoylcysteine synthetase from Enterococcus faecalis.Kinetic basis for the conjugation of auxin by a GH3 family indole-acetic acid-amido synthetase.Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screeningSteady-state and pre-steady-state kinetic analysis of Mycobacterium smegmatis cysteine ligase (MshC).Bacillus anthracis o-succinylbenzoyl-CoA synthetase: reaction kinetics and a novel inhibitor mimicking its reaction intermediateIn-silico Metabolome Target Analysis Towards PanC-based Antimycobacterial Agent Discovery.Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesisReaction intermediate analogues as bisubstrate inhibitors of pantothenate synthetase.Cavitation as a mechanism of substrate discrimination by adenylosuccinate synthetasesBiosynthesis of Pantothenic Acid and Coenzyme A.Mechanism and regulation of mycobactin fatty acyl-AMP ligase FadD33Adenylating enzymes in Mycobacterium tuberculosis as drug targets.Toward the catalytic mechanism of a cysteine ligase (MshC) from Mycobacterium smegmatis: an enzyme involved in the biosynthetic pathway of mycothiol.Advances in Drug Discovery of New Antitubercular Multidrug-Resistant Compounds.Kinetic and inhibition studies of dihydroxybenzoate-AMP ligase from Escherichia coli.Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis.Enterobactin synthetase-catalyzed formation of P(1),P(3)-diadenosine-5'-tetraphosphate.A continuous kinetic assay for adenylation enzyme activity and inhibition.Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency AnalysisPrecise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites.Alanine mutation of the catalytic sites of Pantothenate Synthetase causes distinct conformational changes in the ATP binding region.
P2860
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P2860
Steady-state and pre-steady-state kinetic analysis of Mycobacterium tuberculosis pantothenate synthetase
description
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2001
@ast
im Oktober 2001 veröffentlicher wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/10/30)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/10/30)
@nl
наукова стаття, опублікована в жовтні 2001
@uk
مقالة علمية (نشرت في 30-10-2001)
@ar
name
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@ast
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@en
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@nl
type
label
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@ast
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@en
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@nl
prefLabel
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@ast
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@en
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@nl
P1433
P1476
Steady-state and pre-steady-st ...... ulosis pantothenate synthetase
@en
P2093
J. S. Blanchard
P304
12904–12912
P407
P577
2001-10-30T00:00:00Z