Characterization of the mouse Men1 gene and its expression during development
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Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chainMenin suppresses osteoblast differentiation by antagonizing the AP-1 factor, JunDThe 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor geneGlobal gene expression in neuroendocrine tumors from patients with the MEN1 syndromeMenin, the multiple endocrine neoplasia type 1 gene product, exhibits GTP-hydrolyzing activity in the presence of the tumor metastasis suppressor nm23MEN1 tumor-suppressor protein localizes to telomeres during meiosisReduction of menin expression enhances cell proliferation and is tumorigenic in intestinal epithelial cellsMenin induces apoptosis in murine embryonic fibroblastsConditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissuesA mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumorsComparison of nonsense-mediated mRNA decay efficiency in various murine tissues.Identification of somatic mutations in parathyroid tumors using whole-exome sequencingMenin is a regulator of the stress response in Drosophila melanogasterMenin: a tumor suppressor that mediates postsynaptic receptor expression and synaptogenesis between central neurons of Lymnaea stagnalis.Cells lacking IKKα show nuclear cyclin D1 overexpression and a neoplastic phenotype: role of IKKα as a tumor suppressorMenin represses tumorigenesis via repressing cell proliferation.Of mice and MEN1: Insulinomas in a conditional mouse knockout.Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).The Cell Death Inhibitor ARC Is Induced in a Tissue-Specific Manner by Deletion of the Tumor Suppressor Gene Men1, but Not Required for Tumor Development and Growth.Animal models of pituitary neoplasiaMultiple endocrine neoplasia type 1 (MEN1) as a cancer predisposition syndrome: clues into the mechanisms of MEN1-related carcinogenesis.Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.Recapitulation of pancreatic neuroendocrine tumors in human multiple endocrine neoplasia type I syndrome via Pdx1-directed inactivation of Men1.Menin and bone metabolism.Menin: a scaffold protein that controls gene expression and cell signaling.Inactivation of menin, the product of the multiple endocrine neoplasia type 1 gene, inhibits the commitment of multipotential mesenchymal stem cells into the osteoblast lineage.Tumor suppressor menin is required for subunit-specific nAChR α5 transcription and nAChR-dependent presynaptic facilitation in cultured mouse hippocampal neurons.Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas.Two proteolytic fragments of menin coordinate the nuclear transcription and postsynaptic clustering of neurotransmitter receptors during synaptogenesis between Lymnaea neurons.Characterization of the MEN1 gene product, menin, by site-specific polyclonal antibodies.p18Ink4c, but not p27Kip1, collaborates with Men1 to suppress neuroendocrine organ tumors.Functional studies of the MEN1 gene.Correlation of mutant menin stability with clinical expression of multiple endocrine neoplasia type 1 and its incomplete forms.Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein.Multiple Endocrine Neoplasia Syndromes from Genetic and Epigenetic Perspectives.
P2860
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P2860
Characterization of the mouse Men1 gene and its expression during development
description
1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1998
@ast
im November 1998 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 1998/11/12)
@sk
vědecký článek publikovaný v roce 1998
@cs
wetenschappelijk artikel (gepubliceerd op 1998/11/12)
@nl
наукова стаття, опублікована в листопаді 1998
@uk
مقالة علمية (نشرت في 12-11-1998)
@ar
name
Characterization of the mouse Men1 gene and its expression during development
@ast
Characterization of the mouse Men1 gene and its expression during development
@en
Characterization of the mouse Men1 gene and its expression during development
@nl
type
label
Characterization of the mouse Men1 gene and its expression during development
@ast
Characterization of the mouse Men1 gene and its expression during development
@en
Characterization of the mouse Men1 gene and its expression during development
@nl
prefLabel
Characterization of the mouse Men1 gene and its expression during development
@ast
Characterization of the mouse Men1 gene and its expression during development
@en
Characterization of the mouse Men1 gene and its expression during development
@nl
P2093
P3181
P356
P1433
P1476
Characterization of the mouse Men1 gene and its expression during development
@en
P2093
A. Calender
C. Larsson
C. Stewart
C. Z. Xian
D. Quincey
F. Farnebo
F. Parente
G. F. Carle
P2888
P304
P3181
P356
10.1038/SJ.ONC.1202164
P407
P577
1998-11-12T00:00:00Z
P5875
P6179
1036297427